中国农业科技导报 ›› 2018, Vol. 20 ›› Issue (4): 52-60.DOI: 10.13304/j.nykjdb.2017.0339

• 生物技术 生命科学 • 上一篇    下一篇

人参皂苷生物转化的研究进展

蔡小雨1,闫培生1*,高秀君1,陈琪琪1,郭长禄1,刘润东2,梁浩2,张明臣2   

  1. 1.哈尔滨工业大学(威海)海洋科学与技术学院, 山东 威海 264209; 2.山东安然纳米实业发展有限公司, 山东 威海 264209
  • 收稿日期:2017-05-22 出版日期:2018-04-15 发布日期:2017-08-01
  • 通讯作者: 闫培生,教授,博士生导师,研究方向为微生物发酵工程与制药研究。E-mail:yps6@163.com
  • 作者简介:蔡小雨,硕士研究生,研究方向为微生物与天然产物化学。E-mail:caixiaoyu1992@163.com。
  • 基金资助:
    山东安然纳米实业发展有限公司科技创新项目(ITBA19402006)资助。

Research Progress of Ginsenoside Biotransformation

CAI Xiaoyu1, YAN Peisheng1*, GAO Xiujun1, CHEN Qiqi1, GUO Changlu1,LIU Rundong2, LIANG Hao2, ZHANG Mingchen2   

  1. 1.School of Marine Science and Technology, Harbin Institute of Technology (Weihai), Shandong Weihai 264209;2.Shandong Anran Nano Industrial Development Co., Ltd., Shandong Weihai 264209, China
  • Received:2017-05-22 Online:2018-04-15 Published:2017-08-01

摘要: 人参皂苷和稀有人参皂苷是人参属植物的主要活性成分,而稀有人参皂苷具有极高的药理活性,但是在人参属植物中的含量较低,因此通过生物转化得到稀有人参皂苷具有一定的研究价值。目前已有食品级微生物和各种糖苷酶、蜗牛酶等应用到人参皂苷的生物转化中。综述了人参皂苷的种类及功效、酶法和微生物转化法转化人参皂苷的工艺条件和产物,为稀有人参皂苷的大批量工业化生产提供有益的参考。

关键词: 人参皂苷, 药理活性, 生物转化, 工艺条件

Abstract: Ginsenoside and rare ginsenosides are the main active ingredient of Panax species. Rare ginsenosides have very high pharmacological activity, but low content in Panax species. Therefore, it is of research value to obtain rare ginsenosides by biotransformation. At present, there are food-grade microorganisms and various glycosidases, snail enzymes, etc. being applied to ginsenoside biotransformation.This paper reviewed the types and efficacies of ginsenoside, bio-enzymatic and microbial fermentation of ginsenosides biosynthesis products and technological conditions, which provided beneficial references for large quantity industrial production of rare ginsenosides.

Key words: rare ginsenoside, pharmacological effect, biotransformation, technological conditions