关键词: 碳储存调控系统, csrA基因, 非编码RNA, 群体感应, 生物膜

Abstract:

CsrA was initially found and named during research on the carbon storage regulatory system. CsrA affects stability and translation of target genes by binding mRNA as a widespread post\|transcriptional regulator in Enterobacterium, Pseudomonas, Bacillus and other microorganisms. Studies indicated that CsrA not only regulated a number of physiological processes such as central carbon metabolism, motility, biofilm formation, quorum sensing, and pathogenicity, but also influenced the synthesis of many secondary metabolites. Recent research showed that the functions of CsrA were strictly related to two non\|coding RNAs; these three genes coordinated to form a complex system. This review introduced the various functions of CsrA in different bacteria and its regulatory mechanism, information that will be useful for learning more about the regulatory mechanism of the carbon storage system and alter it for future studies.

Key words: carbon storage regulatory system, csrA, no\, coding RNA, quorum sensing, biofilm