关键词: 烯丙孕素内服溶液, 临床药效, 靶动物安全性, 同期发情, 母猪

Abstract: In order to provide basis for new veterinary drug registration and clinical rational application, the clinical effect and target animal safety of domestic altrenogest oral solution were investigated. The clinical effect of altrenogest oral solution in regulation of synchronous estrus in mature sows was evaluated by estrus interval, estrus rate, concentration ratio of estrus, pregnancy rate and etc. The target animal safety of altrenogest oral solution in mature sows was evaluated by comparison of clinical signs, blood routine and serum biochemical  indexes and histopathology before and after administration. In experimental clinical trials, mature sows were divided into domestic altrenogest oral solution groups with the high (25 mg·d-1), middle (20 mg·d-1) and low (5 mg·d-1) dose and blank control group, estrus interval of above four groups were (3.45±0.81)(3.35±0.66)(5.21±2.65) and (11.71±5.39) d, and estrus rate were 100% (20/20), 100% (20/20), 95% (19/20) and 70% (7/10), respectively. In expanded clinical trials, domestic altrenogest oral solution group and imported drug control group both showed good clinical effect of synchronous estrus in mature sows, estrus interval were (3.45±0.81) and (3.35±0.66) d, oestrus rate were 96.72% (59/61) and 98.33% (59/60), respectively. In target ainimal safety test, within the oral administration at 5-fold recommended dose of 100 mg·d-1, domestic altrenogest oral solution was safe and had no adverse reactions to blood physiological and biochemical functions and main organs of mature sows. In conclusion，the results indicated that domestic altrenogest oral solution was safe and effective in regulation of synchronous estrus in mature sows at the recommended dose of 20 mg·d-1 for successive 18 d.

Key words: altrenogest oral solution, clinical effect, target animal safety, synchronous estrus, mature sows