禽疱疹病毒活载体疫苗研究进展

doi:10.13304/j.nykjdb.2019.0535

中国农业科技导报 ›› 2020, Vol. 22 ›› Issue (3): 85-93.DOI: 10.13304/j.nykjdb.2019.0535

禽疱疹病毒活载体疫苗研究进展

王梦阁,吴英*,程安春*,汪铭书,朱德康,贾仁勇,刘马峰,陈舜,赵新新,杨乔,张沙秋,黄娟,刘韵雅,张玲,于艳玲

四川农业大学动物医学院禽病防治研究中心, 预防兽医研究所, 动物疫病与人类健康四川省重点实验室, 成都 611130

收稿日期:2019-07-01 出版日期:2020-03-15 发布日期:2019-09-25
通讯作者: *通信作者吴英 E-mail：wuy@sicau.edu.cn；程安春 E-mail：chenganchun@vip.163.com
作者简介:王梦阁 E-mail：742950015@qq.com
基金资助:
国家重点研发计划项目（2017YFD0500800）；国家自然科学基金项目（31602079）；现代农业产业技术体系专项(CARS-42-17)；四川省教育厅重点项目(17ZA0309)；四川省科技厅苗子工程项目(2017-2018)。

Research Progress on Live Vectored Vaccine of Avian Herpes Virus

WANG Mengge, WU Ying*, CHENG Anchun*, WANG Mingshu, ZHU Dekang, JIA Renyong, LIU Mafeng, CHEN Shun, ZHAO Xinxin, YANG Qiao, ZHANG Shaqiu, HUANG Juan, LIU Yunya, ZHANG Ling, YU Yanling

Institute of Preventive Veterinary Medicine; Animal Epidemic Disease and Human Health Sichuan Provincial Key Laboratory, Poultry Disease Prevention and Control Research Center Sichuan Agricultural University, Chengdu 611103, China

Received:2019-07-01 Online:2020-03-15 Published:2019-09-25

摘要/Abstract

摘要： 禽疱疹病毒主要包括α疱疹病毒亚科的鸡马立克氏病毒( Mareks disease virus, MDV)、传染性喉气管炎病毒( infectious laryngotracheitis virus, IBDV )和鸭肠炎病毒( duck enteritis virus, DEV )。作为疱疹病毒家族的成员，禽疱疹病毒基因组庞大，存在多个复制非必需区，可容纳多个外源基因的插入，是表达其他禽类病原抗原基因的理想载体。总结了禽疱疹病毒的构建方法、外源基因表达水平，并对MDV、IBDV和DEV 三种禽疱疹病毒的不同重组病毒疫苗免疫效果评价进行归纳，旨在为畜禽传染病防治提供参考依据。

关键词: 禽疱疹病毒, 活载体疫苗, MDV, IBDV, DEV

Abstract: Avian herpesvirus mainly includes Mareks disease virus (MDV), infectious laryngotracheitis virus (IBDV) and duck enteritis virus (DEV), which all belong to α-herpes virus subfamily. As a member of the herpesvirus family, avian herpesvirus has a huge genome, and it has many replication non-essential regions, which can accommodate the insertion of multi-exogenous genes. Thus it is an ideal vector for expressing other avian pathogenic antigen genes. This paper summarized the construction method and expression level of exogenous gene of avian herpesvirus, the immune effect evaluation of different recombinant virus vaccines of MDV, IBDV and DEV was summarized as well, thus providing reference for the prevention and control of infectious diseases in livestock and poultry.

Key words: avian herpes virus, live vector vaccine, MDV, IBDV, DEV

王梦阁,吴英*,程安春*,汪铭书,朱德康,贾仁勇,刘马峰,陈舜,赵新新,杨乔,张沙秋,黄娟,刘韵雅,张玲,于艳玲. 禽疱疹病毒活载体疫苗研究进展[J]. 中国农业科技导报, 2020, 22(3): 85-93.

WANG Mengge, WU Ying*, CHENG Anchun*, WANG Mingshu, ZHU Dekang, JIA Renyong, LIU Mafeng, CHEN Shun, ZHAO Xinxin, YANG Qiao, ZHANG Shaqiu, HUANG Juan, LIU Yunya, ZHANG Ling, YU Yanling. Research Progress on Live Vectored Vaccine of Avian Herpes Virus[J]. Journal of Agricultural Science and Technology, 2020, 22(3): 85-93.

禽疱疹病毒活载体疫苗研究进展

Research Progress on Live Vectored Vaccine of Avian Herpes Virus

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