关键词: 诺如病毒;亚单位疫苗;病毒类似颗粒;P粒子

Abstract:

Noroviruses (NVs) are recognized as the leading pathogen causing nonbacterial acute gastroenteritis epidemics. NVs can infect people of all ages and break out all year-round. Infant, children, the elderly and immunodeficiency people are more vulnerable. At present, vaccine is one of the most effective way to prevent (or control) the outbreak of noroviruses disease in clinic. Based on this, this paper reviewed the finding, epidemiological and molecular biological features of noroviruses and the research progress on its subunit vaccine. Through comparing the affinity to human histo-blood group antigen(HBGAs) between virus-like particles (VLPs) and P particles of noroviruses, the advantages and difficulties of producing oral P as subunit vaccine against noroviruses was discussed using plant expression systems especially tomato. The progress on the expressing P particles by transforming tomato in our laboratory was introduced simply, hoping to provide some references for producing oral vaccine by plant expression systems.

Key words: noroviruses, subunit vaccine, virus-like particle, P particle