关键词: Ⅲ型聚酮合酶；细菌；次级代谢；生物工程改造

Abstract:

Type Ⅲ polyketide synthase (PKS) is considered as the simplest PKS in structure. Type Ⅲ PKSs are very common in plants, bacteria and fungi. With the development of genomics, more and more attentions were paid on bacterial type Ⅲ PKSs. In different bacteria, type Ⅲ PKSs show different functions, produce diverse products and display all kinds of biological activities. At the same time, biological engineering modification of bacterial type Ⅲ PKSs has always been the hotspot of research. This article reviewed the recent research progress on type Ⅲ PKSs in bacteria, which has been identified in characteristics, and bacterial type Ⅲ PKSs are divided into 5 groups based on different product structure. Their different structures, functions, and characteristics were discussed, respectively. It is of significant importance for in\|depth studying different bacterial type Ⅲ PKSs and their biological engineering modification.

Key words: type Ⅲ PKS, bacteria, secondary metabolism, biological engineering modification