关键词: NtrC;转录激活蛋白;碳氮代谢;调控机制

Abstract:

NtrBC is a two-component system involved in bacteria nitrogen metabolism regulation, and NtrC is a transcription activator protein in response to environmental signal and activates the transcription of target genes. The past studies have indicated that bacterial NtrC plays important roles in regulating diverse processes including nitrogenous compounds utilization, biological nitrogen fixation, the biosynthesis of biopolymer and maintenance on the carbon-nitrogen balance. Studies on NtrCs overall regulating function are one of the hotspot of microbe metabolic regulatory networks. This paper reviewed the research progress on NtrC in recent years, and described in detail the biological functions of bacterial NtrC, so as to better understand microbian environment adaptation, metabolic diversity, and the molecular mechanism of C-N coupling regulation.

Key words: NtrC, transcription activator protein, carbon-nitrogen metabolism, regulation mechanism