植物ABC转运蛋白与次生代谢产物的跨膜转运

›› 2007, Vol. 9 ›› Issue (3): 32-37.

植物ABC转运蛋白与次生代谢产物的跨膜转运

金宏滨[1,2] 刘东辉[1,2] 左开井[1] 苗志奇[1] 陈玉辉[1] 孙小芬[3] 唐克轩[1,3]

[1]上海交通大学农业与生物学院植物生物技术研究中心、生命科学技术学院、复旦-交大-诺丁汉植物生物技术研发中心,上海200030 [2]沈阳医学院,沈阳110034 [3]复旦大学生命科学学院遗传工程国家重点实验室、复旦-交大-诺丁汉植物生物技术研发中心,上海200433

收稿日期:2007-05-09 出版日期:2007-06-15 发布日期:2009-10-16
通讯作者: 通讯作者唐克轩，教授，博士，主要从事植物分子生物学、植物生物反应器等研究。Tel：021-62932002；E-mail：kxtangl@yaho．corn,kxtangI@163．com
作者简介:金宏滨|博士研究生|讲师|研究方向为药用植物分子生物学。
基金资助:
国家“863”计划和上海市科学技术委员会资助

Plant ABC Transporters and Their Roles in the Transmembrane |Transport of Secondary Metabolites

JIN Hong-bin, LIU Dong-hui, ZUO Kai-jing, MIAO Zhi-qi, CHEN Yu-hui, SUN Xiao-fen, |TANG Ke-xuan

1. Plant Biotechnology Research Center, School of Agriculture and Biology, Fudan-SJTU-Nottingham Plant Biotechnology R＆D Center, School |of Life Science and Technology, Shanghai JiaoTong University, Shanghai 200030|2. Shenyang Medical College, Shenyang 110034; |3. State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan-SJTU-Notting ham Plant Biotechnology R＆D Center, |Fudan University, Shanghai 200433, China

Received:2007-05-09 Online:2007-06-15 Published:2009-10-16

摘要/Abstract

摘要：

ABC（ATP-Binding Cassette）转运蛋白是目前已知最大、功能最广泛的蛋白家族，参与生物体内多种物质的转运，因其在生物体内与肿瘤细胞耐药性等一些重要的生理过程密切相关而引起了人们的广泛关注。研究发现，在已完成全基因组测序的生物中，ABC转运蛋白在拟南芥和水稻中数量最多，推测与植物次生代谢产物的跨膜转运相关。植物产生生物碱、萜类化合物、酚类等大量次生代谢产物，保护植物体免受环境中生物和非生物胁迫的损伤。这些化合物的累积和排泌被高度调节，ABC转运蛋白在其中起着重要的作用。本综述介绍了植物ABC转运蛋白及其在植物次生代谢产物累积和跨膜转运中的研究进展。

关键词: 次生代谢产物植物ABC转运蛋白萜类生物碱酚

Abstract:

ABC （ATP-Binding Cassette） transporters constitute the largest protein family with the most variety of functions. Most of them are involved in transporting many kinds of substrates in living organisms. Because they are closely related to some important biological processes, such as multidrug resistance （MDR） and etc, ABC transporters have attracted more and more researchers＇ attention. ABC transporters are most abundant in Arabidopsis and rice among current sequenced organisms, leading to the hypothesis that plant ABC transporters largely contribute to membrane transport of endogenous secondary metabolites in the plants. Plants produce a large number of secondary metabolites, such as alkaloids, terpenoids and phenols, which can protect plants from being harmed by biotic and abiotic stresses. The accumulation and secretion of these metabolites are highly regulated and ABC transporters play a significant role in the process. In this review, we summarize the related background information and the advances of plant ABC transporters involving in the accumulation and the transmembrane transport of plant secondary metabolites.

Key words: secondary metabolites, plant ABC transporter, terpenoid, alkaloid, phenol ABC

中图分类号:

Q946.8

金宏滨[1,2] 刘东辉[1,2] 左开井[1] 苗志奇[1] 陈玉辉[1] 孙小芬[3] 唐克轩[1,3]. 植物ABC转运蛋白与次生代谢产物的跨膜转运[J]. , 2007, 9(3): 32-37.

JIN Hong-bin, LIU Dong-hui, ZUO Kai-jing, MIAO Zhi-qi, CHEN Yu-hui, SUN Xiao-fen. Plant ABC Transporters and Their Roles in the Transmembrane |Transport of Secondary Metabolites[J]. , 2007, 9(3): 32-37.