›› 2007, Vol. 9 ›› Issue (4): 26-31.

• 综述 • 上一篇    下一篇

转基因技术改良家畜的现状与趋势

童佳 李宁   

  1. 中国农业大学农业生物技术国家重点实验室,北京100094
  • 收稿日期:2007-05-30 修回日期:2007-06-18 出版日期:2007-08-15 发布日期:2009-10-16
  • 通讯作者: 李宁,教授,博士生导师,从事分子生物学与动物基因工程研究。Tel:010-62731146;E—mail:ninglcau@cal1.edu.cn
  • 作者简介:童佳|博士研究生|研究方向为动物转基因与克隆。

Current Status and Tendency of Improving Livestock by Transgenic Technology

TONG Jia| LI Ning   

  1. National Key Laboratory of Agro-biotechnology, China Agricultural University, Beijing 100094, China
  • Received:2007-05-30 Revised:2007-06-18 Online:2007-08-15 Published:2009-10-16

摘要:

2006年8月,全球第一个通过乳腺生物反应器生产的药物ATryn批准上市,这标志着转基因技术在动物农业和生物医药产业的发展进入到一个新的黄金时期.作者从转基因技术的发展状况入手,综述了国内外利用转基因技术应用于改良家畜的研究历史、现状和产业化进展.动物克隆技术的发展不仅极大提高了转基因效率,同时还为家畜基因敲除和定点整合提供了新的途径;转基因动物在药物生产、疾病模型、干细胞治疗和异种器官移植等方向研发速度正在加快;近年来,在转基因动物育种领域,肉质、生长速度等重要生产性状的转基因改良也取得了突破.另一方面,国际上对转基因动物研究及其利用的生物安全性评估也日臻完善.显然,转基因动物产业正在初露端倪,其必将对人类社会发展产生重要的影响.

关键词: 转基因技术 家畜品种改良 生物医药 生物安全

Abstract:

The first authorized medicine-ATryn produced by transgenic goat mammary gland bioreactor has been authorized into global market in Aug. 2006. This symbolizes that the transgenic technology has entered into a new golden-era in animal husbandry and biomedical industry. This paper summarizes the history of adopting transgenic technology in improving livestock abroad and at home and the current status of transgenic animal research and the progress of commercialization. The development of animal cloning technology has not only boosted the transgenic efficiency, but also provided a new way to knockout livestock gene and to fix targeted integration. The transgenic animal research is accelerating the progress of medicine production, disease model, stem cell therapy, and xenotranso plantation. In the area of livestock transgenic breeding, many breakthroughs have been achieved, especially in the improvementof certain important production traits such as meat quality and growth rate, etc. Additionally, the evaluation for the research on transgenic animal and on the biosafety assessment are perfecting daily. Apparently, the industrialization of transgenic animal just begins to display its brilliant future, which will definitely exert a profound impact on the mankind and social development.

Key words: transgenie technology , livestock animal breeding , biomedicine , biosafety

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