关键词: 骨桥蛋白基因；胚胎着床；妊娠维持；繁殖性能；遗传多态性

Abstract:

Osteopontin (OPN), which widely distributes in a variety of tissues including the reproductive system, is a secreted glycosylated phosphoprotein,and possesses various biological activities. OPN’s extensive physiology functions must mediate through its receptor. OPN is an extracellular matrix, which plays an important role in regulating embryo implantation and placenta development through progestational hormone, and participates almost the entire process of reproduction, and becomes one of the candidate genes about reproductive traits of animals in recent years. The structure and location of OPN gene, the biological functions of OPN as well as correlations between OPN gene and reproductive performance of animals are reviewed.

Key words: osteopontin;embryo implantation;pregnancy maintenance;reproductive performance;genetic polymorphism