益生菌Lactobacillus casei Zhang冻干粉对小鼠急性毒性的研究

›› 2009, Vol. 11 ›› Issue (5): 77-82.

益生菌Lactobacillus casei Zhang冻干粉对小鼠急性毒性的研究

孙洁宇1,2,高鹏飞2,麻士卫2,杜瑞亭1,王明芳2,邓承远2,高杰2,张和平1

(1.内蒙古农业大学乳品生物技术与工程教育部重点实验室, 呼和浩特 010018;2.内蒙古轻工科学研究所, 呼和浩特 010050)

收稿日期:2009-05-25 修回日期:2009-07-20 出版日期:2009-10-15 发布日期:2009-10-15
通讯作者: 张和平,教授,博士生导师,主要从事乳品加工和乳品生物技术研究。E-mail:hepingdd@vip.sina.com
作者简介:孙洁宇,主要从事生物制品的研究与开发。
基金资助:
国家863计划项目（2007AA10Z353）资助。

Studies on Acute Toxicity of Lactobacillus casei Zhang Freeze-dried Powder in Mice

SUN Jie-yu1,2, GAO Peng-fei2, MA Shi-wei2, DU Rui-ting1, WANG Ming-fang2, DENG Cheng-yuan2, GAO Jie2, ZHANG He-ping1

(1.Key Laboratory of Dairy Biotechnology and Bioengineer, Ministry of Education, Inner Mongolia Agricultural University,
Hohhot 010018|2.Inner Mongolia Light Industry Research Institute, Hohhot 010050, China)

Received:2009-05-25 Revised:2009-07-20 Online:2009-10-15 Published:2009-10-15

摘要/Abstract

摘要：

通过研究益生菌Lactobacillus casei Zhang冻干粉对小鼠急性毒性作用,为该菌株的安全应用提供依据。连续14 d对小鼠灌胃不同剂量的L.casei Zhang冻干粉,各剂量组小鼠的一般体征、肝脏功能、脏器指数以及肝、肾、脾形态学的观察结果与对照组相比无显著差异（P>0.05）。急性毒性试验及相关指标检测结果显示L.casei Zhang冻干粉无毒副作用。

关键词: Lactobacillus casei Zhang；冻干粉；小鼠；急性毒性试验

Abstract:

The acute toxicity of Lactobacillus casei Zhang freeze-dried powder was studied in mice to provide evidence for safety application. Different dose of L. casei Zhang freeze-dried powder were given to mice by gavage for 14 days. Compared with control, there were no significant differences (P>0.05) in general signs, liver function, organ index and morphology of liver, kidney and spleen of mice administrated with different dose of L. casei Zhang freeze-dried powder. The result of acute toxicity and determination of related indexes showed that L. casei Zhang freeze-dried powder had no toxicity and side effects.

Key words: Lactobacillus casei Zhang, freeze-dried powder, mice, acute toxicity experiment

中图分类号:

孙洁宇1,2,高鹏飞2,麻士卫2,杜瑞亭1,王明芳2,. 益生菌Lactobacillus casei Zhang冻干粉对小鼠急性毒性的研究[J]. , 2009, 11(5): 77-82.

SUN Jie-yu1,2, GAO Peng-fei2, MA Shi-wei2, DU Rui-ting1, WANG Ming-fang2, . Studies on Acute Toxicity of Lactobacillus casei Zhang Freeze-dried Powder in Mice[J]. , 2009, 11(5): 77-82.