农业基因回路设计合成技术发展动态与策略

doi:10.13304/j.nykjdb.2022.1021

中国农业科技导报 ›› 2022, Vol. 24 ›› Issue (12): 101-111.DOI: 10.13304/j.nykjdb.2022.1021

农业基因回路设计合成技术发展动态与策略

林敏¹(), 王磊¹, 谷晓峰², 燕永亮², 刘柱³, 涂涛⁴, 姚斌⁴()

^1.河南大学农学院，中原食品实验室，河南开封 475004
^2.中国农业科学院生物技术研究所，北京 100081
^3.海南大学生命科学学院，海口 570100
^4.中国农业科学院北京畜牧兽医研究所，北京 100091

收稿日期:2022-11-13 接受日期:2022-11-30 出版日期:2022-12-15 发布日期:2023-02-06
通讯作者: 姚斌
作者简介:林敏 E-mail：linmin@henu.edu.cn；
基金资助:
国家自然科学基金未来生物技术指南项目(32150021);国家自然科学基金优秀青年科学基金项目(32222082);国家转基因生物新品种培育重大专项(2019ZX08010-004)

Development Trends and Strategies of Gene Circuit Design and Synthesis Technologies in Agricultural Organisms

Min LIN¹(), Lei WANG¹, Xiaofeng GU², Yongliang YAN², Zhu LIU³, Tao TU⁴, Bin YAO⁴()

^1.Food Laboratory of Zhongyuan，College of Agriculture，Henan University，Henan Kaifeng 475004，China
^2.Biotechnology Research Institute，Chinese Academy of Agricultural Sciences，Beijing 100081，China
^3.School of Life Sciences，Hainan University，Haikou 570100，China
^4.Institute of Animal Sciences，Chinese Academy of Agricultural Sciences，Beijing 100091，China

Received:2022-11-13 Accepted:2022-11-30 Online:2022-12-15 Published:2023-02-06
Contact: Bin YAO

摘要/Abstract

摘要：

随着生物组学、系统生物学和合成生物学等前沿学科的高度交叉融合，推动新一代基因工程技术不断取得新突破。基因回路设计与合成是新一代基因工程的技术核心，具有颠覆性、智能性和精准性三大技术特征。加快农业生物基因回路设计与合成技术等创新，将为创制新一代农业生物新品种和促进我国农业高质量绿色发展提供重要技术支撑。简要总结了农业生物基因回路设计与合成技术国际发展动态，深入探讨了我国农业生物基因智能设计与精准表达技术的发展策略与优先领域。

关键词: 农业生物, 基因回路, 智能设计, 精准表达, 生物合成

Abstract:

With the highly cross-integration of frontier disciplines such as bioomics， systems biology and synthetic biology， the new generation of genetic engineering technology has maked new breakthroughs. Gene circuit design and synthesis is the core technology of the new generation of genetic engineering， and its three technical characteristics are subversion， intelligence and precision. Accelerating the innovation of gene circuit design and synthesis technology of agricultural organisms will provide important technical support for creating a new generation of agricultural varieties and promoting the high-quality green development of Chinese agriculture. In this paper， the international development trends of gene circuit design and synthesis technology of agricultural organisms were summarized， and the development strategies and priority fields of intelligent design and precise expression technology of agricultural biological gene circuit in China were discussed.

Key words: agricultural organisms, gene circuit, intelligent design, precise expression, biosynthesis

中图分类号:

林敏, 王磊, 谷晓峰, 燕永亮, 刘柱, 涂涛, 姚斌. 农业基因回路设计合成技术发展动态与策略[J]. 中国农业科技导报, 2022, 24(12): 101-111.

Min LIN, Lei WANG, Xiaofeng GU, Yongliang YAN, Zhu LIU, Tao TU, Bin YAO. Development Trends and Strategies of Gene Circuit Design and Synthesis Technologies in Agricultural Organisms[J]. Journal of Agricultural Science and Technology, 2022, 24(12): 101-111.

图/表 2

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