Journal of Agricultural Science and Technology ›› 2023, Vol. 25 ›› Issue (11): 123-131.DOI: 10.13304/j.nykjdb.2022.0268
• ANIMAL AND PLANT HEALTH • Previous Articles
Hongbo LI1(), Yueyue CHEN2, Yujie YANG1, Qiqi XU1, Lei QIN1, Xin CAI1, Lining XIA1(
)
Received:
2022-04-05
Accepted:
2022-08-29
Online:
2023-11-15
Published:
2023-11-20
Contact:
Lining XIA
李宏博1(), 陈月月2, 杨玉洁1, 徐琦琦1, 秦蕾1, 蔡鑫1, 夏利宁1(
)
通讯作者:
夏利宁
作者简介:
李宏博 E-mail:1518957065@qq.com;
基金资助:
CLC Number:
Hongbo LI, Yueyue CHEN, Yujie YANG, Qiqi XU, Lei QIN, Xin CAI, Lining XIA. Drug Resistance and Genotype Analysis of Escherichia coli in Healthy Chickens from Zhaosu, Yili, Xinjiang[J]. Journal of Agricultural Science and Technology, 2023, 25(11): 123-131.
李宏博, 陈月月, 杨玉洁, 徐琦琦, 秦蕾, 蔡鑫, 夏利宁. 新疆伊犁昭苏健康鸡源大肠杆菌耐药性及耐药基因分析[J]. 中国农业科技导报, 2023, 25(11): 123-131.
基因名称 | 引物序列 | 片段长度 | 退火温度 | 参考文献 |
---|---|---|---|---|
Gene name | Primer sequence (5’-3’) | Fragment length/bp | Annealing temperature/℃ | Reference |
blaTEM | F: CATTTCCGTGTCGCCCTTATTC | 800 | 56 | [ |
R: CGTTCATCCATAGTTGCCTGAC | ||||
blaCTX-M | F: TTTGCGATGTGCAGTACCAGTAA | 544 | 56 | [ |
R: CGATATCGTTGGTGGTGGCCATA | ||||
blaOXA | F: AAGAAACGCTACTCGCCTGC | 564 | 56 | [ |
R: CCACTCAACCCATCCTACCC | ||||
floR | F: CACGTTGAGCCTCTATAT | 868 | 55 | [ |
R: ATGCAGAAGTAGAACGCG | ||||
fexA | F: CTCTTCTGGACAGGCTGGAA | 332 | 57 | |
R: CCAGTTCCTGCTCCAAGGTA | ||||
fexB | F: ACTCGACACGCACGCTTAAT | 320 | 57 | |
R: CCTCCCCCAAGATACATTGC | ||||
pexA | F: CTTCCAGTTGAGAAGCGAGC | 320 | 59 | |
R: AGAAGCATACCCGTGAACATG | ||||
estDL136 | F: ATGCCGTTAAACCCCCATGTCGAAG | 933 | 55 | |
R: TCAAGCGACGTCTCTTTTAAGATT | ||||
qnrD | F: TTACGGGGAATAGAGTTA | 468 | 55 | [ |
R: AATCAGCCAAAGACCAAT | ||||
qnrS | F: GCAAGTTCATTGAACAGGGT | 619 | 55 | [ |
R: TCTAAACCGTCGAGTTCGGCG | ||||
oqxA | F: CTCGGCGCGATGATGCT | 392 | 68 | [ |
R: CCACTCTTCACGGGAGACGA | ||||
oqxB | F: TTCTCCCCCGGCGGGAAGTAC | 512 | 65 | [ |
R: CTCGGCCATTTTGGCGCGTA | ||||
tet(A) | F: GCGCCTTTCCTTTGGGTTCT | 831 | 53 | [ |
R: CCACCCGTTCCACGTTGTTA |
Table 1 Length of fragment and primer sequence
基因名称 | 引物序列 | 片段长度 | 退火温度 | 参考文献 |
---|---|---|---|---|
Gene name | Primer sequence (5’-3’) | Fragment length/bp | Annealing temperature/℃ | Reference |
blaTEM | F: CATTTCCGTGTCGCCCTTATTC | 800 | 56 | [ |
R: CGTTCATCCATAGTTGCCTGAC | ||||
blaCTX-M | F: TTTGCGATGTGCAGTACCAGTAA | 544 | 56 | [ |
R: CGATATCGTTGGTGGTGGCCATA | ||||
blaOXA | F: AAGAAACGCTACTCGCCTGC | 564 | 56 | [ |
R: CCACTCAACCCATCCTACCC | ||||
floR | F: CACGTTGAGCCTCTATAT | 868 | 55 | [ |
R: ATGCAGAAGTAGAACGCG | ||||
fexA | F: CTCTTCTGGACAGGCTGGAA | 332 | 57 | |
R: CCAGTTCCTGCTCCAAGGTA | ||||
fexB | F: ACTCGACACGCACGCTTAAT | 320 | 57 | |
R: CCTCCCCCAAGATACATTGC | ||||
pexA | F: CTTCCAGTTGAGAAGCGAGC | 320 | 59 | |
R: AGAAGCATACCCGTGAACATG | ||||
estDL136 | F: ATGCCGTTAAACCCCCATGTCGAAG | 933 | 55 | |
R: TCAAGCGACGTCTCTTTTAAGATT | ||||
qnrD | F: TTACGGGGAATAGAGTTA | 468 | 55 | [ |
R: AATCAGCCAAAGACCAAT | ||||
qnrS | F: GCAAGTTCATTGAACAGGGT | 619 | 55 | [ |
R: TCTAAACCGTCGAGTTCGGCG | ||||
oqxA | F: CTCGGCGCGATGATGCT | 392 | 68 | [ |
R: CCACTCTTCACGGGAGACGA | ||||
oqxB | F: TTCTCCCCCGGCGGGAAGTAC | 512 | 65 | [ |
R: CTCGGCCATTTTGGCGCGTA | ||||
tet(A) | F: GCGCCTTTCCTTTGGGTTCT | 831 | 53 | [ |
R: CCACCCGTTCCACGTTGTTA |
基因名称 | 引物序列 | 片段长度 | 退火温度 | 参考文献 |
---|---|---|---|---|
Gene name | Primer sequences (5’-3’) | Fragment length/bp | Annealing temperature/℃ | Reference |
tet(B) | F: TTGGTTAGGGGCAAGTTTTG | 659 | 55 | [ |
R: GTAATGGGCCAATAACACCG | ||||
tet(M) | F: GTGTGACGAACTTTACCGAA | 501 | 46 | [ |
R: GCTTTGTATCTCCAAGAACAC | ||||
tet(K) | F: GTAGTGACAATAAACCTCCTA | 360 | 55 | [ |
R: CCAAGCATCGGCATCTCATA | ||||
acc(6')/aph-(2'') | F: CCAAGAGCAATAAGGGCATA | 220 | 55 | [ |
R: CACTATCATAACCACTACCG | ||||
aph(3')-Ⅲ | F: GCCGATGTGGATTGCGAAAA | 292 | 55 | |
R: GCTTGATCCCCAGTAAGTCA | ||||
ant(3'')-Ⅰa | F: ATCTGGCTATCTTGCTGACA | 284 | 54 | [ |
R: TATGACGGGCTGATACTGG | ||||
aac6'-Ⅰb | F: ATGACCTTGCGATGCTCTAGA | 486 | 54 | [ |
R: CGAATGCCTGGCGTGTTT | ||||
ant(4',4'') | F: GCAAGGACCGACAACATTTC | 165 | 55 | [ |
R: TGGCACAGATGGTCATAACC | ||||
mcr-1 | F: CGGTCAGTCCGTTTGTTC | 309 | 55 | [ |
R: CTTGGTCGGTCTGTAGGG |
Table 1 Length of fragment and primer sequence
基因名称 | 引物序列 | 片段长度 | 退火温度 | 参考文献 |
---|---|---|---|---|
Gene name | Primer sequences (5’-3’) | Fragment length/bp | Annealing temperature/℃ | Reference |
tet(B) | F: TTGGTTAGGGGCAAGTTTTG | 659 | 55 | [ |
R: GTAATGGGCCAATAACACCG | ||||
tet(M) | F: GTGTGACGAACTTTACCGAA | 501 | 46 | [ |
R: GCTTTGTATCTCCAAGAACAC | ||||
tet(K) | F: GTAGTGACAATAAACCTCCTA | 360 | 55 | [ |
R: CCAAGCATCGGCATCTCATA | ||||
acc(6')/aph-(2'') | F: CCAAGAGCAATAAGGGCATA | 220 | 55 | [ |
R: CACTATCATAACCACTACCG | ||||
aph(3')-Ⅲ | F: GCCGATGTGGATTGCGAAAA | 292 | 55 | |
R: GCTTGATCCCCAGTAAGTCA | ||||
ant(3'')-Ⅰa | F: ATCTGGCTATCTTGCTGACA | 284 | 54 | [ |
R: TATGACGGGCTGATACTGG | ||||
aac6'-Ⅰb | F: ATGACCTTGCGATGCTCTAGA | 486 | 54 | [ |
R: CGAATGCCTGGCGTGTTT | ||||
ant(4',4'') | F: GCAAGGACCGACAACATTTC | 165 | 55 | [ |
R: TGGCACAGATGGTCATAACC | ||||
mcr-1 | F: CGGTCAGTCCGTTTGTTC | 309 | 55 | [ |
R: CTTGGTCGGTCTGTAGGG |
来源 Source | 样品数 Number of samples | 检出数 Number of isolates | 分离率 Isolation rate/% |
---|---|---|---|
克马克加尔村Kemakgar village | 200 | 194 | 97.0 |
森塔斯村 Sentas village | 20 | 20 | 100.0 |
乌克勒加尔村 Uklegar village | 80 | 75 | 93.8 |
总计 Total | 300 | 289 | 96.3 |
Table 2 Isolation of Escherichia coli from chicken in Zhaosu, Yili
来源 Source | 样品数 Number of samples | 检出数 Number of isolates | 分离率 Isolation rate/% |
---|---|---|---|
克马克加尔村Kemakgar village | 200 | 194 | 97.0 |
森塔斯村 Sentas village | 20 | 20 | 100.0 |
乌克勒加尔村 Uklegar village | 80 | 75 | 93.8 |
总计 Total | 300 | 289 | 96.3 |
抗菌药物 Antibiotics | 耐药率 Resistance rate/% | |||
---|---|---|---|---|
克马克加尔村 Kemakgar village | 森塔斯村 Sentas village | 乌克勒加尔村 Uklegar village | 总计 Total | |
氨苄西林AMP | 37.6 Bb | 40.0 Aa | 13.3 Cc | 31.5 |
头孢唑啉CFZ | 21.6 Bb | 35.0 Aa | 8.0 Cc | 19.0 |
头孢噻呋TIO | 11.3 Ab | 20.0 Aa | 4.0 Ac | 10.4 |
氟苯尼考FFC | 27.8 Ab | 45.0 Aa | 16.0 Ac | 26.0 |
四环素TET | 25.8 Aa | 5.0 Cc | 9.3 Bb | 20.1 |
恩诺沙星ENR | 14.9 Bb | 40.0 Aa | 2.7 Cc | 13.5 |
庆大霉素GEN | 1.7 Ab | 10.0 Aa | 0.0 Ac | 2.4 |
阿米卡星AMK | 0.0 | 0.0 | 0.0 | 0.0 |
硫酸粘菌素COL | 6.2 Bb | 30.0 Aa | 0.0 Cc | 6.2 |
Table 3 Resistant rate of Escherichia coli on ten kinds of antimicrobial agents
抗菌药物 Antibiotics | 耐药率 Resistance rate/% | |||
---|---|---|---|---|
克马克加尔村 Kemakgar village | 森塔斯村 Sentas village | 乌克勒加尔村 Uklegar village | 总计 Total | |
氨苄西林AMP | 37.6 Bb | 40.0 Aa | 13.3 Cc | 31.5 |
头孢唑啉CFZ | 21.6 Bb | 35.0 Aa | 8.0 Cc | 19.0 |
头孢噻呋TIO | 11.3 Ab | 20.0 Aa | 4.0 Ac | 10.4 |
氟苯尼考FFC | 27.8 Ab | 45.0 Aa | 16.0 Ac | 26.0 |
四环素TET | 25.8 Aa | 5.0 Cc | 9.3 Bb | 20.1 |
恩诺沙星ENR | 14.9 Bb | 40.0 Aa | 2.7 Cc | 13.5 |
庆大霉素GEN | 1.7 Ab | 10.0 Aa | 0.0 Ac | 2.4 |
阿米卡星AMK | 0.0 | 0.0 | 0.0 | 0.0 |
硫酸粘菌素COL | 6.2 Bb | 30.0 Aa | 0.0 Cc | 6.2 |
来源 Source | 百分比Percentage/% | |||||||
---|---|---|---|---|---|---|---|---|
1耐 1 resistance | 2耐 2 resistance | 3耐 3 resistance | 4耐 4 resistance | 5耐 5 resistance | 6耐 6 resistance | 7耐 7 resistance | 合计 Total | |
克马克加尔村 Kemakgar village | 42.6 | 25.4 | 12.3 | 4.1 | 7.4 | 5.7 | 2.5 | 62.9 |
森塔斯村 Sentas village | 0.0 | 35.7 | 21.4 | 14.3 | 21.4 | 7.1 | 0.0 | 70.0 |
乌克勒加尔村 Uklegar village | 45.0 | 30.0 | 5.0 | 20.0 | 0.0 | 0.0 | 0.0 | 26.6 |
合计 Total | 39.1 | 26.9 | 12.2 | 7.1 | 7.7 | 5.1 | 1.9 | 54.0 |
Table 4 Multidrug resistant condition of Escherichia coli
来源 Source | 百分比Percentage/% | |||||||
---|---|---|---|---|---|---|---|---|
1耐 1 resistance | 2耐 2 resistance | 3耐 3 resistance | 4耐 4 resistance | 5耐 5 resistance | 6耐 6 resistance | 7耐 7 resistance | 合计 Total | |
克马克加尔村 Kemakgar village | 42.6 | 25.4 | 12.3 | 4.1 | 7.4 | 5.7 | 2.5 | 62.9 |
森塔斯村 Sentas village | 0.0 | 35.7 | 21.4 | 14.3 | 21.4 | 7.1 | 0.0 | 70.0 |
乌克勒加尔村 Uklegar village | 45.0 | 30.0 | 5.0 | 20.0 | 0.0 | 0.0 | 0.0 | 26.6 |
合计 Total | 39.1 | 26.9 | 12.2 | 7.1 | 7.7 | 5.1 | 1.9 | 54.0 |
基因 Gene | 检出率Detection rate/% | |||
---|---|---|---|---|
克马克加尔村 Kemakgar village | 森塔斯村 Sentas village | 乌克勒加尔村 Uklegar village | 总计 Total | |
blaTEM | 22.7 Aa | 20.0 Aa | 5.3 Bb | 18.0 |
blaCTX-M | 7.7 Aa | 15.0 Aa | 6.7 Aa | 8.0 |
floR | 25.8 Aa | 50.0 Aa | 18.7 Aa | 25.6 |
oqxA | 3.1 Aa | 0.0 Aa | 1.3 Aa | 2.4 |
oqxB | 2.6 Aa | 0.0 Aa | 2.7 Aa | 2.4 |
tet(A) | 21.1 Aa | 20.0 Aa | 9.3 Aa | 18.0 |
tet(M) | 1.0 Aa | 0.0 Aa | 0.0 Aa | 0.7 |
ant(3″)-Ⅰa | 1.0 Aa | 0.0 Aa | 0.0 Aa | 0.7 |
mcr-1 | 0.5 Aa | 0.0 Aa | 0.0 Aa | 0.3 |
Table 5 Detection rate of drug resistance genes in Escherichia coli
基因 Gene | 检出率Detection rate/% | |||
---|---|---|---|---|
克马克加尔村 Kemakgar village | 森塔斯村 Sentas village | 乌克勒加尔村 Uklegar village | 总计 Total | |
blaTEM | 22.7 Aa | 20.0 Aa | 5.3 Bb | 18.0 |
blaCTX-M | 7.7 Aa | 15.0 Aa | 6.7 Aa | 8.0 |
floR | 25.8 Aa | 50.0 Aa | 18.7 Aa | 25.6 |
oqxA | 3.1 Aa | 0.0 Aa | 1.3 Aa | 2.4 |
oqxB | 2.6 Aa | 0.0 Aa | 2.7 Aa | 2.4 |
tet(A) | 21.1 Aa | 20.0 Aa | 9.3 Aa | 18.0 |
tet(M) | 1.0 Aa | 0.0 Aa | 0.0 Aa | 0.7 |
ant(3″)-Ⅰa | 1.0 Aa | 0.0 Aa | 0.0 Aa | 0.7 |
mcr-1 | 0.5 Aa | 0.0 Aa | 0.0 Aa | 0.3 |
耐药基因 Drug resistance gene | 耐药基因检出率 Detection rate of drug resistance gene/% | 耐药率/% Drug resistance rate/% | 耐药种类 Type of drug resistance |
---|---|---|---|
blaTEM blaCTX-M blaTEM+blaCTX-M | 9.3 | 36.0 | β-内酰胺类 β-lactams |
floR | 25.6 | 26.0 | 酰胺醇类 Amide alcohols |
tet(A) tet(M) | 18.7 | 20.1 | 四环素类 Tetracyclines |
oqxa oqxb oqxa+oqxb | 2.8 | 13.8 | 喹诺酮类 Quinolones |
ant(3'')-Ⅰa | 0.7 | 2.4 | 氨基糖苷类 Aminoglycosides |
mcr-1 | 0.3 | 6.2 | 多肽类 Polypeptides |
Table 6 Comparison of detection rate of drug resistance gene and drug resistance phenotype
耐药基因 Drug resistance gene | 耐药基因检出率 Detection rate of drug resistance gene/% | 耐药率/% Drug resistance rate/% | 耐药种类 Type of drug resistance |
---|---|---|---|
blaTEM blaCTX-M blaTEM+blaCTX-M | 9.3 | 36.0 | β-内酰胺类 β-lactams |
floR | 25.6 | 26.0 | 酰胺醇类 Amide alcohols |
tet(A) tet(M) | 18.7 | 20.1 | 四环素类 Tetracyclines |
oqxa oqxb oqxa+oqxb | 2.8 | 13.8 | 喹诺酮类 Quinolones |
ant(3'')-Ⅰa | 0.7 | 2.4 | 氨基糖苷类 Aminoglycosides |
mcr-1 | 0.3 | 6.2 | 多肽类 Polypeptides |
1 | OH Y I, SEO K W, KIM D H, et al.. Prevalence, co-infection and seasonality of fecal enteropathogens from diarrheic cats in the Republic of Korea (2016-2019): a retrospective study [J/OL]. BMC Vet. Res., 2021, 17(1):367 [2022-03-10]. . |
2 | 殷泽禄,万虎.大肠杆菌的研究综述[J].甘肃畜牧兽医,2019,49(5):33-35. |
3 | WOOLEY R E, GIBBS P S, BROWN T P, et al.. Chicken embryo lethality assay for determining the virulence of avian Escherichia coli isolates [J]. Avian Dis., 2000, 44(2):318-324. |
4 | 李灶平.食品中大肠埃希氏、沙门氏菌耐药性与整合子的关系研究[D].成都:四川大学,2004. |
LI Z P. Incidence and characterization of integrons in Escherichia coli and Salmonella spp. strains isolated from food [D]. Chendu: Sichuan University, 2004. | |
5 | 刘建华.鸭源大肠杆菌主动外排基因及其调控基因的表达水平与多重耐药机制[D].郑州:河南农业大学,2011. |
LIU J H. The expression level of active efflux system related genes and mechanism of multidrug resistance in E . coli isolated from ducks [D]. Zhengzhou: Henan Agricultural University, 2011. | |
6 | 刘洋.多药耐药基因cfr在动物源肠球菌中的传播机制[D].北京:中国农业大学,2013. |
LIU Y. Transmission mechanism of multidrug resistance gene cfr in Enterococcus of animal origin [D]. Beijing: China Agricultural University, 2013. | |
7 | Clincal and Laboratory Standards Institute. Performance standards for antimicrobial susceptibility testing 2016:M100-S26 [S]. Clincal and Laboratory Standards Institute, 2016. |
8 | 张青娴,徐引弟,王治方,等.猪源产超广谱β-内酰胺酶大肠杆菌的耐药性调查与耐药基因型分析[J].养猪,2019(4):105-108. |
9 | 吴立婷.扬州地区宠物源大肠杆菌耐药性分析及耐药基因检测[D].扬州:扬州大学,2017. |
WU L T. Detection and analysis of drug resistance genes among Escherichia coli isolated from companion animals in Yangzhou area [D]. Yangzhou: Yangzhou University, 2017. | |
10 | 刘保光,栗俞程,汪保英,等.CTX-M型超广谱β-内酰胺酶研究进展[J].河南农业科学,2019,48(12):1-7. |
LIU B G, LI Y C, WANG B Y, et al.. Research progress of CTX-M Type extended-spectrum β-lactamases [J]. J. Henan Agric. Sci., 2019, 48(12):1-7. | |
11 | 周倩,张小燕,马尹鹏,等.蛋鸡投喂氟苯尼考后大肠杆菌耐药性变化及耐药基因检测[J].中国家禽,2020,42(9):40-46. |
ZHOU Q, ZHANG X Y, MA Y P, et al.. Changes of drug resistance and detection of florfenicol resistance genes in Escherichia coli isolated from laying hens after florfenicol administration [J]. China Poultry, 2020, 42(9):40-46. | |
12 | 南海辰.新疆不同动物源喹诺酮类耐药大肠杆菌PMQR因子流行性调查[D].乌鲁木齐:新疆农业大学,2014. |
NAN H C. Epidemic investigation of PMQR factor among quinolone-resistance Escherichia coli from different animal sources in Xinjiang [D]. Urumqi: Xinjiang Agricultural University, 2014. | |
13 | 杜伟伟.河北省乳源金黄色葡萄球菌耐药性检测及耐药基因的研究[D].保定:河北农业大学,2015. |
DU W W. Research on drug resistence and resistant genes of the Staphylococcus aureus from raw milk in province of Hebei [D]. Baoding: Hebei Agricultural University, 2015. | |
14 | BACCI C, BONI E, ALPIGIANI I, et al.. Phenotypic and genotypic features of antibiotic resistance in Salmonella enterica isolated from chicken meat and chicken and quail carcasses [J]. Int. J. Food Microbiol., 2012, 160(1):16-23. |
15 | 孔海深,徐根云,李雪芬,等.耐甲氧西林金黄色葡萄球菌多重耐药基因检测[J].中华检验医学杂志,2005,28(10):57-59. |
KONG H S, XUE G Y, LI X F, et al.. The detection of clinically relevant antibiotic resistance genes in Staphylococcus aureus [J]. Chin. J. Lab. Med., 2005, 28(10):57-59. | |
16 | 黄琴.猪源大肠杆菌耐药表型和基因型研究[D].广州:华南理工大学, 2018. |
HUANG Q. Phenotypic and genotypic characterization in Escherichia coli isolates from swine [D]. Guangzhou: South China University of Technology, 2018. | |
17 | 宋方宇.生鲜肉中金黄色葡萄球菌的分离鉴定及其耐药性研究[D].泰安:山东农业大学,2018. |
SONG F Y. Isolation and identification of Stapltylococcus aureus from fresh meat and study on its antibiotic resistance [D]. Tai’an: Shandong Agricultural University, 2018. | |
18 | 高芸,轩慧勇,姚晓慧,等.MALDI-TOF质谱技术对猪肠道菌群中携带mcr-1细菌的鉴定与聚类分型[J/OL].中国动物传染病学报,2022:1-10[2022-01-14]. . |
GAO Y, XUAN H Y, YAO X H, et al.. Identification and typing of mcr-1-carrying bacteria strains isolated from pig gut flora by Maldi-T of mass spectrometry [J/OL]. Chin. J. Anim. Infect. Dis., 2022: 1-10 [2022-01-14]. . | |
19 | PUVAČA N, DE L, FRUTOS R. Antimicrobial resistance in Escherichia coli strains isolated from humans and pet animals [J/OL]. Antibiotics (Basel), 2021, 10(1): 69. [2022-01-14]. . |
20 | 唐标,郝运,林家辉,等.浙江省2市动物源大肠埃希菌及肠球菌耐药性比较和分析[J].浙江大学学报(农业与生命科学版),2021,47(5):647-659. |
TANG B, HAO Y, LIN J H, et al.. Comparison and analysis of antimicrobial resistance of Escherichia coli and Enterococcus isolated from animals in Jinhua City and Taizhou City of Zhejiang Province [J]. J. Zhejiang Univ. Agric. Life Sci., 2021, 47(5):647-659. | |
21 | 张海龙.河北省鸡源大肠杆菌的分离鉴定及毒力与耐药性检测[D].秦皇岛:河北科技师范学院,2021. |
ZHANG H L. Isolation and identification of Escherichia coli from chickens in Hebei Province and detection of virulence and drug resistance [D]. Qinghuangdao: Hebei Normal University of Science and Technology, 2021. | |
22 | ALHABABI D A, ELTAI N O, NASRALLAH G K, et al.. Antimicrobial resistance of commensal Escherichia coli isolated from food animals in Qatar [J]. Microbiol. Drug Resist., 2020, 26(4):420-427. |
23 | 徐小艳,王国相,印继华,等.1975~2002年大肠杆菌耐药性变化情况调查[J].畜牧与兽医.2003,35(3):16-17. |
24 | 高玉斌,赵格,邹明,等.我国不同区域鸡源大肠杆菌的致病性与耐药性状分析[J].中国兽医杂志,2019,55(3):81-84, 89. |
GAO Y B, ZHAO G, ZOU M, et al.. Analysis of virulence gene carrying and drug resistance of Escherichia coli isolated from chickens in different regions of China [J]. Chin. J. Vet. Med. 2019, 55(3):81-84, 89. | |
25 | 林居纯,卓家珍,蒋红霞,等.不同地区猪源和禽源大肠杆菌耐药性监测[J].华南农业大学学报,2009,30(1):86-88, 93. |
LIN J C, ZHUO J Z, JIANG H X, et al.. Surveillance of antimicrobial resistance among Escherichia coli isolates from swine and poultry in different regions [J]. J. South China Agric. Univ., 2009, 30(1):86-88, 93. | |
26 | 陈伟.动物源大肠杆菌耐药基因与HPI毒力基因的检测及相关性分析[D].合肥:安徽农业大学,2013. |
CHEN W. Detection and correlation analysis of resistance and HPI virulence genes in Escherichia coli from animals. [D]. Hefei: Anhui Agricultural University, 2013. | |
27 | 陈月月,王凯,王舒丰,等.新疆伊犁地区不同动物源大肠杆菌耐药性调查[J].新疆农业科学,2018,55(8):1560-1568. |
CHEN Y Y, WANG K, WANG S F, et al.. Investigation into drug resistance of Escherichia coli from different animal sources in Yili, Xinjiang [J]. Xinjiang Agric. Sci., 2018, 55(8):1560-1568. | |
28 | 于桂阳,郑春芳,黄杰河.湖南永州市鸡大肠杆菌的耐药性调查与分析[J].家禽科学,2014(3):14-17. |
29 | 郑生国.猪病防治过程中正确使用抗菌药物的方法探讨[J].畜禽业,2022,33(1):51-52. |
30 | 王彬婷.鸡源大肠杆菌ESBL和PMQR基因流行分布及其传播特性研究[D].合肥:安徽农业大学,2014. |
WANG B T. Prevalence and characteristics of extended-spectrum β-lactamase and plasmid-mediated fluoroquinolone resistance genes in Escherichia coli isolated from chickens [D]. Hefei: Anhui Agricultural University, 2014. | |
31 | 贺志沛,王玲飞,刘建华,等.宠物犬源大肠杆菌氟苯尼考耐药基因floR的检测及药物敏感性分析[J].中国畜牧兽医,2013,40(6):211-215. |
HE Z P, WANG L F, LIU J H, et al.. Detection of floR gene in Escherichia coli isolated from pet dogs and investigation of antibiotic susceptibility [J]. Chin. Anim. Husb. Vet. Med., 2013, 40(6):211-215. | |
32 | 张雅为,高锋,刘耀川,等.阜新某鸡场大肠埃希菌四环素类药物敏感性试验及耐药基因检测[J].动物医学进展,2017,38(10):118-121. |
ZHANG Y W, GAO F, LIU Y C, et al.. Tetracycline sensitivity test and drug resistance gene detection of Escherichia coli in one chicken farm of Fuxin [J]. Pro. Vet. Med., 2017, 38(10):118-121. | |
33 | 王凤军.四环素类抗生素抗药性研究进展[J].现代畜牧科技,2021(12):11-13, 44. |
WANG F J. Research progress of betracycline antibiotic resistance [J]. Mod. Anim. Husb. Sci. Tech., 2021(12):11-13, 44. | |
34 | 邵微豪,韩雨婕,殷瑜,等.基于斑马鱼模型的4种氨基糖苷类药物的耳肾毒性比较[J].中国医药工业杂志,2021,52(7):934-939. |
SHAO W H, HAN Y J, YIN Y, et al.. Comparison of oto-and renal toxicities of four aminoglycosides in zebrafish [J]. Chin. J. Pharm., 2021, 52(7):934-939. | |
35 | 吕东月,汪照国,王鑫.耐药基因blaNDM-1和mcr-1在肠道细菌中的研究进展[J].中国人兽共患病学报,2020,36(8):660-664. |
LYU D Y, WANG Z G, WANG X. Research progress of drug resistance of intestinal bacteria antibiotic resistance genes blaNDM-1 and mcr-1 [J]. Chin. J. Zoonoses, 2020, 36(8):660-664. | |
36 | TONG H, LIU J, YAO X, et al.. High carriage rate of mcr-1 and antimicrobial resistance profiles of mcr-1-positive Escherichia coli isolates in swine faecal samples collected from eighteen provinces in China [J]. Vet. Microbiol., 2018, 225:53-57. |
37 | NANG S C, LI J, VELKOV T. The rise and spread of mcr plasmid-mediated polymyxin resistance [J]. Crit. Rev. Microbiol., 2019, 45(2):131-161. |
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