Abstract:

Deinococcus radiodurans, as a model organism in DNA damage and repair, is the most resistant bacterium to ionizing radiation. In this paper, recent research progresses on DNA repair mechanism, including the structure characteristic, molecular defense mechanism, important repair genes, genomics, and proteomics of D. radiodurans are summarized. Further research based on alternative genetic and biochemical approaches should help to gain a better understanding of the special mechanism involved in DNA repair.

Key words: Deinococcus radiodurans , DNA repair, proteomics , genomics

摘要：

耐辐射球菌是迄今为止发现的最耐辐射的原核生物,是研究DNA损伤与修复的模式生物.根据国内外实验室和本实验在耐辐射球菌研究上取得的最新研究成果,本文从该细菌的结构特征、分子防御机制、重要修复基因、基因组学和蛋白质组学等方面综述了耐辐射球菌在DNA修复机制方面取得的进展,探讨了未来揭示该细菌独特高效的DNA修复分子机理可能采取的途径.

关键词: 耐辐射球菌 DNA修复 蛋白质组学 基因组学