多表位疫苗的构建策略及其在动物疫苗中的应用

›› 2008, Vol. 10 ›› Issue (2): 29-33.

多表位疫苗的构建策略及其在动物疫苗中的应用

张有峰[1] 王红宁[2] 黄勇[1] 阳泰[2]

[1]四川农业大学动物科技学院,动物预防医学与生物工程实验室,四川雅安625014 [2]四川大学生命科学学院,动物疾病防控生物工程研究中心,四川大学“985工程”西南资源环境与灾害防治科技创新平台,成都610064

收稿日期:2007-12-24 修回日期:2008-01-23 出版日期:2008-04-15 发布日期:2009-07-29
通讯作者: 王红宁，教授，博士，博士生导师，主要从事畜禽传染病的预防研究。E-mail.whongning@163．com
作者简介:张有峰|硕士研究生|主要从事畜禽传染病研究。E-mail：xinfang1206@163．com。
基金资助:
国家863项目（2006AA10A205）资助.

Construction Strategy for Multiepitope Vaccine and its |Application in Animal Vaccine

ZHANG You-feng, WANG Hong-ning, HUANG Yong| YANG Tai

1. Laboratory of Animal Preventive Medicine and Bioengineering, College of Animal Science and Technology, Sichuan Agricultural |University, Sichuan Ya＇an 625014|2. Life Science College, Sichuan University, Bioengineering Research Center for |Animal Disease Prevention and Control, Sichuan University ＂985 project＂ Science Innovative Platform |for Resource and Environment Protection of Southwestern China, Chengdu 610064, China

Received:2007-12-24 Revised:2008-01-23 Online:2008-04-15 Published:2009-07-29

摘要/Abstract

摘要：

多表位疫苗是基于抗原表位氨基酸序列而制备的一种新型分子疫苗。由于具有安全性好、保护力强和应答类型可以有效调控等优点，多表位疫苗具有较高的研究和应用价值。多表位疫苗因其独特的免疫优势已成为近年来基因工程疫苗研究领域的热点之一。本文概述了表位的预测筛选、多表位疫苗的设计与优化及其在动物医学领域的应用等方面的进展。

关键词: 多表位疫苗抗原表位 T细胞表位 B细胞表位

Abstract:

Multiepitope vaccine is a new kind of molecular vaccine based on the aminophenol sequence of antigenic epitopes. It has higher value in research and application for its safe security, strong protective ability and effectual regulative reaction in immune response types. Multiepitope vaccine has recently become one of the hotspots in the field of gene engineering vaccine, due to its unusual immune advantages. This paper summarizes the research progress in multiepitope vaccine on prediction and selection of epitopes, its designing, optimization and application in veterinary medicine.

Key words: multiepitope vaccine , antigenic epitope , T-cell epitope , B-cell epitope

中图分类号:

S852.43

张有峰,王红宁,黄勇,阳泰. 多表位疫苗的构建策略及其在动物疫苗中的应用[J]. , 2008, 10(2): 29-33.

ZHANG You-feng, WANG Hong-ning, HUANG Yong| YANG Tai. Construction Strategy for Multiepitope Vaccine and its |Application in Animal Vaccine[J]. , 2008, 10(2): 29-33.