关键词: 玉米低聚肽, CCl4, 小鼠, 保护肝脏

Abstract:

To explore the protective effect of corn oligopeptide(COP) on CCl4-induced acute hepatic injury of mouse, this experiment carried out precautions for liver injury by intragastric infusion orally with COP daily dose of 200 mg/kg·d, 400 mg/kg·d, 800 mg/kg·d to mice. After 30 d, a dose of 10 mg/kg and 0.5% CCl4 was intragastric infused. 16 h later mouse liver index, the value of malondialdehyde (MDA), superoxide dismutase (SOD), glutathion peroxidase (GSH-px) and the contents of serum alanine aminotransferase (ALT) and glutamic-oxalacetic transaminease(AST) were measured. The pathological changes in hepatic tissues of each group were observed. The result showed that COP at high and middle doses could all significantly reduce the levels of AST, ALT and MDA of liver injured mouse caused by CCl4 (P<0.05) and improved their SOD and GSH-Px vigor (P<0.05). COP could also promote the recovery of mouse liver function, but had little effect on liver index. Under microscope, it could be observed that COP improved mouse hepatic injury. The above results indicated that COP can protect CCl4-induced acute liver damage of mouse.

Key words: corn oligopeptide, CCl4, mice, hepato-protective function