Research Progress in the Production of Transgenic Animals Using Spermatogonial Stem Cells

›› 2009, Vol. 11 ›› Issue (1): 40-44.

Previous Articles Next Articles

Research Progress in the Production of Transgenic Animals Using Spermatogonial Stem Cells

HANG Xin1,2, MIAO Xiangyang1, YIN Xunhe2, MA Yan-fang2,

1.Institute of Animal Science, Chinese Academy of Agricultural Siences, Beijing |100193|2.Animal Science and Technology, Shandong Agricultural University, Shandong Taian |271018|3.College of Life Science, Northeast University of Forestry, Harbin 150040, China

Received:2008-10-13 Revised:2008-11-17 Online:2009-02-15 Published:2009-07-29

利用精原干细胞建立转基因动物的研究进展

张鑫1,2,苗向阳1,尹逊河2,马艳芳2,曲朝杰1,2,张秋婷1,3

1.中国农业科学院北京畜牧兽医研究所, 北京 100193|2.山东农业大学动物科技学院, 山东 |泰安 271018|
3.东北林业大学生命科学院, 哈尔滨150040

通讯作者: 苗向阳,副研究员,从事基因工程与功能基因组学及转基因动物研究。Tel： 010-62895663； E-mail：mxy32@sohu.com
作者简介:张鑫,硕士研究生,从事动物解剖学及转基因动物研究。Tel： 010-62895663； E-mail：sanjin1983@yahoo.com.cn。
基金资助:
国家自然科学基金项目（30571339）;国家863计划项目（2008AA10Z140）;中国农业科学院创新基金项目（2004-院-1）;中国农业科学院优秀科技创新团队项目（ywf-td-1）资助。

Abstract

Abstract:

Spermatogonial stem cells (SSCs) are kinds of adult stem cells in male mammalia. They are not only the ones capable of selfrenewing and differentiating in testis niche,but also the only ones in normal postnatal body that undergo selfrenewal throughout life and transmit gene to offspring. SSCs have significant value in producing transgenic animals. The origin, formation, type and differentiation of SSCs were reviewed. The application of SSCs in transgenic animals was also summarized.

Key words: spermatogonial stem cells, transgene, animal

摘要：

精原干细胞(spermatogonial stem cells,SSCs)是雄性哺乳动物体内的一种成体干细胞,在睾丸微环境中既具有自我更新潜能,又具有定向分化潜能,是自然状态下出生后,动物体内在整个生命期间进行自我更新并能将基因传递至子代的唯一成体干细胞。精原干细胞在建立转基因动物中具有重要的应用价值,现已成为转基因研究领域的热点之一。介绍了精原干细胞的来源、形成、类型及分化,同时对其在转基因动物研究中的应用做一综述。

关键词: 精原干细胞；转基因；动物

CLC Number:

S814.8

HANG Xin1,2, MIAO Xiangyang1, YIN Xunhe2, MA Yan-fang2, . Research Progress in the Production of Transgenic Animals Using Spermatogonial Stem Cells[J]. , 2009, 11(1): 40-44.

张鑫1,2,苗向阳1,尹逊河2,马艳芳2,曲朝杰1,2,张秋婷1,3.
利用精原干细胞建立转基因动物的研究进展[J]. , 2009, 11(1): 40-44.

[1]	SHANG Bin, TAO Xiuping, DONG Hongmin, CHEN Yongxing, ZHANG Wanqin, YIN Fubin. Research Status and Prospect of Alkaline Hydrothermal Technology for Livestock Carcasses Disposal [J]. Journal of Agricultural Science and Technology, 2021, 23(8): 136-141.
[2]	LIANG Ying, LIU Senhong, SHEN Yujun, DING Jingtao, MENG Haibo, ZHANG Pengyue. Effects of Various Acidifiers on Inorganic Nitrogen Forms Transformation in Animal Slurry [J]. Journal of Agricultural Science and Technology, 2021, 23(8): 142-153.
[3]	SUN Kangtai1, ZHANG Jianmin2, JIANG Dawei3, WANG Xiaolong4,GE Yiqiang1, DENG Xiaoming1*. Progress and Countermeasures of Antimicrobial Resistance of Animal Origin Bacterial Pathogens in China [J]. Journal of Agricultural Science and Technology, 2020, 22(5): 1-5.
[4]	TANG Xiaopeng, CHEN Lei, XIONG Kangning*. Application Prospect of EM Bacteria in Agricultural Production of Guizhou Karst Region [J]. Journal of Agricultural Science and Technology, 2020, 22(4): 129-138.
[5]	YANG Haifeng1,2§, LI Yanyan1,2§, CHEN Xiaolan1, YAO Shiyun1, HUANG Yaqi2, XIA Liangyou2, LI Yuchen2, BU Shijin2*. Clinical Effect and Target Animal Safety of Altrenogest Oral Solution [J]. Journal of Agricultural Science and Technology, 2020, 22(1): 78-86.
[6]	PEI Huaidi1, LI Zhongwang1, CHEN Yuliang2, LUO Junjie1*. Transgenic Potato Plant with GhABF2 and Its Drought Tolerance Analysis [J]. Journal of Agricultural Science and Technology, 2019, 21(11): 35-42.
[7]	YANG Haifeng1,2, LI Yongjun1,3*, LU Guangfu1,3. Clinical Therapeutic Effect and Target Ainimal Safety of Praziquantel Injection [J]. Journal of Agricultural Science and Technology, 2017, 19(6): 46-54.
[8]	WANG Haibin1,2, ZHANG Qingxu1, CHEN Xiaoting1, MA Xiaomao1, ZHAO Hu1,YE Jianghua2,3, KONG Xianghai1. Effect of Animal Manure on Soil Acidity and Microbe of Tea Tree Rhizosphere [J]. Journal of Agricultural Science and Technology, 2017, 19(5): 115-122.
[9]	TAO Xiuping, DONG Hongmin*. Research Progress on Animal Waste Treatment and Recycling Technology [J]. Journal of Agricultural Science and Technology, 2017, 19(1): 37-42.
[10]	LU Chang-hua, HE Kong-wang, HU Yi-nong, TAN Ye-ping, YU Da-wei. Construction and Development of Animal Disease Risk Analysis System in China [J]. Journal of Agricultural Science and Technology, 2016, 18(5): 8-16.
[11]	YIN Fu-bin1, JI Chao2, DONG Hong-min1*, TAO Xiu-ping1, CHEN Yong-xing1. Research Progress on Effect of Antibiotic on Anaerobic Digestion Treatment in Animal Manure [J]. Journal of Agricultural Science and Technology, 2016, 18(5): 171-177.
[12]	CHEN Xiao, CHEN Chao, LIU Zhi-guang, WANG Hui-hua, GUO Hai-kun, SHI Wei*. Research Progress on Genetic Evaluation of the Main Quantitative Traits of Honeybee [J]. Journal of Agricultural Science and Technology, 2016, 18(4): 58-63.
[13]	ZHAO Yong1,2,3, SHEN Wei3, ZHANG Hong-fu1*. Research Progress on Effects of Air Particle Matters, NH3 and H2S on Animal Fertility and Performance [J]. Journal of Agricultural Science and Technology, 2016, 18(4): 132-138.
[14]	ZHANG Kai, ZHANG Jun-min*, ZHAO Qing-yu. Advances on Residues and Detection of β-Agonists in Animal Hair [J]. Journal of Agricultural Science and Technology, 2016, 18(2): 41-46.
[15]	CHEN Hui-ping, ZHANG Yan-rong*, HUANG Bing-kai. An Empirical Study on Factors Affecting Herbivorous Animal Husbandry Competitiveness based on Co-integration Analysis ——Taking Gansu Province as a Case [J]. Journal of Agricultural Science and Technology, 2016, 18(2): 192-199.

Research Progress in the Production of Transgenic Animals Using Spermatogonial Stem Cells

利用精原干细胞建立转基因动物的研究进展

PDF

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics