Simultaneous Determination of 13 Sulfonamides in Porcine Meat by Ultra Performance Liquid Chromatography Tandem Mass Spectrometry

›› 2009, Vol. 11 ›› Issue (S1): 35-38.

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Simultaneous Determination of 13 Sulfonamides in Porcine Meat by Ultra Performance Liquid Chromatography Tandem Mass Spectrometry

YAN Feng, CAO Ying, LI Dan-ni, ZHANG Wen-gang, JIANG Yin, ZHANG Xin, GU Xin

(Shanghai Supervisory Institute of Veterinary Drugs and Feedstaff, Shanghai 201103, China)

Received:2009-09-02 Revised:2009-10-09 Online:2009-12-16 Published:2009-11-27

猪肉中13种磺胺类药物多残留检测超高效液相-串联质谱法

严凤,曹莹,李丹妮,张文刚,蒋音,张鑫,顾欣

(上海兽药饲料检测所, 上海 201103)

通讯作者: 顾欣,研究员,主要从事药物残留检测分析研究。Tel:02162688731;Email:guxun@sh163.net
作者简介:严凤,助理畜牧师,研究方向为兽药残留分析。

Abstract

Abstract:

A ultra performance liquid chromatography-tandem mass spectrometric (UPLC/MS/MS) method was developed for simultaneous determination of 13 sulfonamides in the porcine meat. Components were extracted from homogenized sample with acetonitrile, defatted by n-hexane and further extracted by Alumia B. The limit of determination (LOD) was 0.25 μg/kg. The method was proved to be satisfactory in precision, securacy and sensitivity for multiresidues determination.

Key words: sulfonamide, residues analysis, ultra performance liquid chromatographytandem mass spectrometry

摘要：

建立了用超高效液相-串联质谱仪检测猪肉中种磺胺多残留的方法。采用乙腈提取,正己烷去脂,碱性氧化铝柱净化后,用超高效液相-串联质谱仪进行定性及定量分析。方法最低检出限为0.25 μg/kg。方法灵敏、准确,可实现多种磺胺激素同时进行定性及定量分析。

关键词: 磺胺;残留分析;超高效液相-串联质谱

CLC Number:

S816.17

YAN Feng, CAO Ying, LI Dan-ni, ZHANG Wen-gang, JIANG Yin, ZHANG Xin, GU Xin. Simultaneous Determination of 13 Sulfonamides in Porcine Meat by Ultra Performance Liquid Chromatography Tandem Mass Spectrometry[J]. , 2009, 11(S1): 35-38.

严凤,曹莹,李丹妮,张文刚,蒋音,张鑫,顾欣. 猪肉中13种磺胺类药物多残留检测超高效液相-串联质谱法[J]. , 2009, 11(S1): 35-38.

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Simultaneous Determination of 13 Sulfonamides in Porcine Meat by Ultra Performance Liquid Chromatography Tandem Mass Spectrometry

猪肉中13种磺胺类药物多残留检测超高效液相-串联质谱法

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