Abstract:

When exposed to a medium with multi-carbon sources, most bacteria can use one preferred carbon source and prevent the metabolism and utilization of other compounds through decreasing the expression of corresponding genes by repression protein of carbon metabolism. This is called as carbon catabolism repression and widespread in bacteria, which is one of the hotspot of microbe metabolizability research. Through selective utilization of the carbon sources, bacteria obtain high competition and adaptation ability in their living niches. The protein of catabolism repression could play a role through complicated regulation systems, including transcription of activation or repression and control translation of related genes. There are some differences between the class of acting proteins and mechanisms in different bacteria. This review summarized some kind of acting proteins and mechanisms of CRC, which contributed to convince the environment adaption and metabolic diversity and the molecular regulation of carbon metabolism in bacteria.

Key words: preferred carbon sources, carbon catabolism repression control, regulation mechanism

摘要：

当生长介质中存在多种碳源时,细菌通常选择利用某一种优先碳源,同时在碳代谢抑制蛋白参与下抑制其他碳源的代谢和利用。这种碳代谢抑制现象广泛存在于细菌中,是当前微生物代谢研究的热点和前沿之一。通过对碳源的选择性优先利用,细菌可以在生存环境中保持高度的竞争力和环境适应能力。碳代谢抑制蛋白通过复杂的调控网络发挥作用,主要通过转录水平上的激活/抑制或者与RNA结合蛋白的翻译控制等方式进行。在不同微生物中,碳代谢抑制蛋白的种类及其作用机制存在一定的差异。综述了目前研究较为深入的几种细菌中的碳代谢抑制蛋白及其作用机制,将有助于深化微生物的环境适应性,代谢多样性和碳代谢分子调控的认识。

关键词: 优先碳源;碳代谢抑制;调节机制