关键词: 碳代谢抑制调控；假单胞菌；CbrAB；CrcZ；Crc

Abstract:

In the complex environment, microorganism select to use the perferred carbon source by carbon catabolite repression(CCR) and at the same time inhibit the non\|perferred carbon sources, so as to achieve the best growth and metabolism procedure. This phenomenon is widespread in bacteria, but there exist differences among different species. In Escherichia coli, CRP protein plays the core role, while in Pseudomonas, the CbrAB\|CrcZ\|Crc system is critical. Crc protein is a global regulator. CrcZ is a newly identified non\|coding regulatory RNA, whose expression is regulated by 2 component system CbrAB. The whole regulatory process is under complex and efficient control. Combining the related international recent progresses and our laboratory work, this paper introduced in detail the regulation mechanism of CCR by CbrAB\|CrcZ\|Crc regulation system in Pseudomonas, expected to improve our awareness about the regulatory mechanism of carbon metabolism and microorganisms adaptability to environment.

Key words: carbon metabolism inhibition and control, Pseudomonas, CbrAB, CrcZ, Crc