›› 2011, Vol. 13 ›› Issue (4): 53-57.DOI: 10.3969/j.issn.1008-0864.2011.04.08

• 生物技术 生命科学 • 上一篇    下一篇

EAR转录抑制子结构及功能的研究

张健飞,权瑞党,黄荣峰   

  1. (中国农业科学院生物技术研究所, 北京 100081)
  • 收稿日期:2011-04-01 修回日期:2011-04-19 出版日期:2011-08-15 发布日期:2011-06-14
  • 通讯作者: 黄荣峰,研究员,博士生导师,主要从事植物抗逆生物学及作物育种研究。Tel:010-82106143; E-mail:rfhuang@caas.net.cn
  • 作者简介:张健飞,硕士研究生,研究方向为植物分子抗逆生物学。E-mail:jf.cambrian@gmail.com。
  • 基金资助:

    国家自然科学基金重点项目(30730060);国家转基因生物新品种培育重大专项(2009ZX08009-020B)资助。

Studies on Structure and Function of Repressors with EAR Motif

ZHANG Jian-fei, QUAN Rui-dang, HUANG Rong-feng   

  1. (Biotechnology Research Institute, Chinese Academy of Agricultural Sciences, Beijing 100081, China)
  • Received:2011-04-01 Revised:2011-04-19 Online:2011-08-15 Published:2011-06-14

摘要:

EAR基序作为主动抑制子的抑制结构域存在于ERF,C2H2和AUX/IAA等转录因子家族成员。EAR基序具有非常保守的氨基酸序列,即L/FDLNL/F(x)P和LxLxL。含有EAR基序的转录因子通过负调控生长发育和非生物胁迫及生物胁迫应答相关基因的表达,从而使植物在不同环境下保持正常的生理状态。综述了EAR主动抑制子在进化上的意义、分类、作用机理以及相关基因的研究进展,并结合本实验室的研究对EAR抑制子的研究趋势及应用前景予以展望。

关键词: EAR基序;主动抑制子;转录调控;转录因子

Abstract:

Ethylene-responsive element binding factor-associated amphiphilic repression (EAR) motif exists in transcription factor families, such as ERF, C2H2 and AUX/IAA. The EAR motif contains two distinct conservation patterns: L/FDLNL/F(x)P and LxLxL. Through negatively regulating expression of genes involved in development, abiotic and biotic stress responses, plants can keep suitable physiological states under different environmental conditions. This review discusses the evolutionary significance of EAR motif and its patterns, the progress on gene regulation mechanisms and function studies. In addition, combing with our work in laboratory, prospective trends of EAR-related research are predicted.

Key words: EAR motif, active repressor, transcriptional regulation, transcription factor

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