麻保沙星在中国对虾体内药代动力学及残留研究

›› 2008, Vol. 10 ›› Issue (2): 88-93.

麻保沙星在中国对虾体内药代动力学及残留研究

张海珍[1,2] 李健[2] 王群[2] 刘淇[2] 周一兵[1]

[1]大连水产学院生命科学与技术学院,辽宁大连116023 [2]中国水产科学研究院黄海水产研究所,农业部海洋渔业资源可持续利用重点开放实验室,山东青岛266071

收稿日期:2008-02-28 修回日期:2008-03-05 出版日期:2008-04-15 发布日期:2009-07-29
通讯作者: 李健，研究员，主要从事海水健康养殖和水产药理学研究。Tel：0532-85830183；E-mail：lijian@ysfri．ac．cn.
作者简介:张海珍|硕士研究生|主要从事水产药理学研究。E-mail：oceanzhz@163．com。
基金资助:
国家科技支撑计划（2006BAD01A13）,公益性农业行业科研专项（nyhyzx07-042）和科研院所社会公益研究专项（2004DIB4J165）资助.

Studies on Pharmacokinetics and Residues of |Marbofloxacin in Penaeus chinensis

ZHANG Hai-zhen, LI Jian| WANG Qun, LIU Qi, ZH0U, Yi-bing

1. College of Life Sciences and Biotechnology, Dalian Fisheries University, Liaoning Dalian 116023 ; |2. Key 0pen Laboratory of Ministry of Agriculture for Sustainable Utilization of Marine FiShery Resources, Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Shandong Qingdao,266071, China

Received:2008-02-28 Revised:2008-03-05 Online:2008-04-15 Published:2009-07-29

摘要/Abstract

摘要：

高效液相色谱法测定水温20±1℃条件下，2．5mg·kg^-1剂量肌注和口服麻保沙星在中国对虾体内的药代动力学及残留规律。采用3p97药动学软件处理数据，结果表明：肌注给药的药时数据符合一级吸收二室、开放模型，主要药动学参数如下：血淋巴、肌肉、肝胰腺内的Tmax和Cmax分别为0．147h．0．039h．0．103h和3．688μg·mL^-1、2．7331μg·mL^-1、4．524μg·mL^-1，AUC分别为8．474μg·mL^-1·h^-1、2．396μg·mL^-1·h^-1、18．310μg·mL^-1·h^-1（1／2）。为0．893h,0．103h、1．257h；t（1／2）B为9．866h、2．648h,4．947h，CL为0．118L·h^-1·kg^-1、1．043L·h^-1·kg^-1、0．137L·h^-1·k^-1。连续口服给药三种组织中消除半衰期分别为8．74h,55．14h．5．72h。根据本试验结果及多剂量给药原则，麻保沙星的合理给药方案为：口服2．5mg·kg^-1的剂量，每日1次给药。

关键词: 中国对虾麻保沙星药动学残留

Abstract:

This paper reports pharmacokinetics and residues of marbofloxacin in Fenneropenaeus chinensis at 20 ± 1℃. Hemolymph、muscle and hepatopancreas were sampled after intrmuscular administration and repeat oral administration at a dose of 2.5mg·kg^- 1 body weight. The concentration of medicament in tisssues was determined by HPLC. The data were analyzed with the pharmacokinetics computer program 3p97. The concentration-time course of marbofloxacin in the tissues could be described by a two-compartment open model. The main pharmacokinetics parameters in hemo- lymph,muscle and hepatopancreas were as follows： Tmax 0. 147 h,0.039 h,0. 103 h; Cmax 3.688μg·mL^-1、2.731μg·mL^-1、4.524μg·mL^-1,AUC 8.474μg·mL^-1·h^-1、2.396μg·mL^-1·h^-1、18.3100μg·mL^-1·h^-1（1/2）.0.893h,0.103h、1.257h;t（1/2）B 9.866h、2.648h,4.947h,CL 0.118L·h^-1·kg^-1、1.043L·h^-1·kg^-1、0.137L·h^-1·k^-1 After repeat oral administration, t（1/2）~were 8.74 h,5.14 h,5.72 h. Base on the data above, we suggested Fenneropenaeus chinensis could take marbofloxacin once per day by oral administration （2.5mg · kg^-1）.

Key words: Fenneropenaeus chinensis , marbofloxaein , pharmaeokineties , residues

中图分类号:

S859.79

张海珍,李健,王群,刘淇,周一兵. 麻保沙星在中国对虾体内药代动力学及残留研究[J]. , 2008, 10(2): 88-93.

ZHANG Hai-zhen, LI Jian| WANG Qun, LIU Qi, ZH0U, Yi-bing . Studies on Pharmacokinetics and Residues of |Marbofloxacin in Penaeus chinensis[J]. , 2008, 10(2): 88-93.