Abstract: Pesticide solid nanodispersion is a novel formulation proposed by the combination of nanotechnology and preparation technology of solid dispersion, which is a solidified nanoformulation with pesticide compound in the form of particles and microcrystallines dispersed in a solid hydrophilic matrix. This formulation can avoid the use of any organic solvent and substantially reduce the surfactant content, overcome poor stability bottleneck of the water-based nanoformulations. In addition, the formulation can improve the dispersibility, adhesion and permeability of poorly water-soluble pesticide, and further enhance the bioavailability so to reduce pesticides dosage and residual contamination. This article summarized the preparation methods of solid nanodispersions and their applications in the field of pesticide and medicine. Based on the low efficacy and high residue of pesticide, application of the solid nanodispersion as a new type of pesticide formulation is crucial and has important realistic significance.

Key words: pesticide, solid nanodispersion, preparation method

摘要： 农药固体纳米分散体是将纳米技术与农药固体分散体制备技术相结合的一种农药新剂型，是药物以纳米尺度的微粒、微晶形态均匀分散在固态水溶性载体中形成的固体纳米剂型。该剂型在杜绝有机溶剂和大幅度减少表面活性剂用量的同时，克服了水基化纳米剂型稳定性差的瓶颈问题，提高了难溶性农药在水中的分散性，有利于增加农药在叶面的粘附性和渗透性，进而提高其生物利用度，节约农药使用量，降低残留污染。综述了固体纳米分散体在农药和医药领域的研究进展及其主要制备方法，基于目前农药使用过程中有效利用率低及残留污染严重的问题，探析高效、环保的固体纳米分散体作为一种新型农药剂型的应用前景具有重要的现实意义。

关键词: 农药, 固体纳米分散体, 制备方法