Research Progress on Crossed Beak in Chicken

doi:10.13304/j.nykjdb.2021.0799

Journal of Agricultural Science and Technology ›› 2022, Vol. 24 ›› Issue (11): 35-42.DOI: 10.13304/j.nykjdb.2021.0799

• BIOTECHNOLOGY & LIFE SCIENCE • Previous Articles Next Articles

Research Progress on Crossed Beak in Chicken

Lei SHI¹^,²(), Yanyan SUN¹, Yunlei LI¹, Hao BAI³^,⁴, Jilan CHEN¹()

^1.Key Laboratory of Animal （Poultry） Genetic Breeding and Reproduction，Ministry of Agriculture and Rural Affairs； Institute of Animal Sciences，Chinese Academy of Agricultural Sciences，Beijing 100193，China
^2.College of Animal Science and Technology，Hebei Agricultural University，Hebei Baoding 071001，China
^3.College of Animal Science and Technology，Yangzhou University，Jiangsu Yangzhou 225009，China
^4.Joint International Research Laboratory of Agriculture and Agri-Product Safety，Ministry of Education； Institutes of Agricultural Science and Technology Development，Yangzhou University，Jiangsu Yangzhou 225009，China

Received:2021-09-10 Accepted:2021-12-22 Online:2022-11-15 Published:2022-11-29
Contact: Jilan CHEN

鸡交叉喙研究进展

石雷¹^,²(), 孙研研¹, 李云雷¹, 白皓³^,⁴, 陈继兰¹()

^1.中国农业科学院北京畜牧兽医研究所, 农业部动物遗传育种与繁殖(家禽)重点实验室, 北京 100193
^2.河北农业大学动物科技学院, 河北保定 071001
^3.扬州大学动物科学与技术学院, 江苏扬州 225009
^4.扬州大学农业科技发展研究院, 教育部农业与农产品安全国际合作联合实验室, 江苏扬州 225009

通讯作者: 陈继兰
作者简介:石雷 E-mail： shilei2017@foxmail.com；
基金资助:
北京市科技计划课题项目(D171100007817005);财政部与农业农村部国家现代农业产业技术体系建设专项(CARS-40);农业农村部动物遗传育种与繁殖（家禽）重点实验室开放课题项目(Poultrylab2019-1);中国农业科学院科技创新工程项目(ASTIP-IAS-04)

Abstract

Abstract:

Crossed beak is a complex trait regulated by many genes， and the prevalence of this trait was documented in at least 12 chicken strains worldly including commercial strains and native chickens. The crossed beak is a deformity， which is defined as misalignment of the upper and lower beak， and does not become apparent until the chicks in 1 and 2 months old. Crossed beaks have reduced feeding and drinking， poor production performance， and caused great animal welfare problem. The mandibular curvature occurred much more than maxilla. Crossed beaks is characterized by impaired development of unilateral mandibular ramus. Recently， many candidate factors， such as LOC426217， BMP4， FIGNL1 genes and parvalbumin and lipoprotein lipase etc. were identified related to crossed beak. This review summarized research progress of phenotype characterization， mode of transmission， and genetic mechanisms of crossed beaks in chickens， and aimed at supporting better understanding and mechanism exploration of this trait and reducing its occurance.

Key words: chicken, crossed beak, inheritance, morphological development, regulation mechanism

摘要：

交叉喙是多基因控制的复杂性状，目前已在全球至少12个鸡种中报道，包括商业品种和地方品种。交叉喙鸡刚出壳时喙形正常，但在随后1~2个月内逐渐呈现上下喙交错、咬合不全的交叉状态。交叉喙严重影响个体采食和饮水、降低生产性能、损害动物福利。交叉喙以下喙偏离中线为主，原因是单侧下颌骨支发育缓慢，LOC426217、BMP4、FIGNL1基因和脂蛋白脂肪酶、清蛋白等与该性状的发生相关。综述了鸡交叉喙表型特征、遗传方式和分子调控机制等方面的研究进展，以期为深入解析该性状的遗传基础和降低发病率提供借鉴。

关键词: 鸡, 交叉喙, 遗传规律, 形态发育, 分子机制

CLC Number:

S831

Lei SHI, Yanyan SUN, Yunlei LI, Hao BAI, Jilan CHEN. Research Progress on Crossed Beak in Chicken[J]. Journal of Agricultural Science and Technology, 2022, 24(11): 35-42.

石雷, 孙研研, 李云雷, 白皓, 陈继兰. 鸡交叉喙研究进展[J]. 中国农业科技导报, 2022, 24(11): 35-42.

Figures/Tables 3

References 51

1	BENKMAN C W, LINDHOLM A K. The advantages and evolution of a morphological novelty [J]. Nature, 1991, 349(6309): 519-520.
2	CHEN B L, HAITH K L, MULLENS B A. Beak condition drives abundance and grooming-mediated competitive asymmetry in a poultry ectoparasite community [J]. Parasitology, 2011, 138(6): 748-757.
3	GIUSEPPE V, MULLENS B A, MENCH J A. Relationships between beak condition, preening behavior and ectoparasite infestation levels in laying hens [J]. Poult. Sci., 2015, 94(9): 1997-2007.
4	HONG Y, PANG Y, ZHAO H, et al.. The morphology of cross-beaks and BMP4 gene expression in huiyang bearded chickens [J/OL]. Animals, 2019, 9(12):1143 [2021-11-07]. .
5	JOLLER S, BERTSCHINGER F, KUMP E, et al.. Crossed beaks in a local Swiss chicken breed [J/OL]. BMC Vet. Res., 2018, 14(1):68 [2021-11-07]..
6	BAI H, SUN Y Y, LIU N, et al.. Genome-wide detection of CNVs associated with beak deformity in chickens using high-density 600K SNP arrays [J]. Anim. Genet., 2018, 49(3): 226-236.
7	白皓,孙研研,陈继兰.喙畸形研究进展 [J].畜牧兽医学报, 2016, 47(3): 417-422.
	BAI H, SUN Y Y, CHEN J L. The research progress of beak deformity [J]. Chin. J. Anim. Vet. Sci., 2016, 47(3): 417-422.
8	GERRITSEN A F C, HEEZIK Y M V, SWENNEN C. Chemoreception in two further calidris species (C. maritima and C. canutus) with a comparison of the relative importance of chemoreception during foraging in calidris species [J]. Neth. J. Zool., 1982, 33(4): 485-496.
9	DEMERY Z P, CHAPPELL J, MARTIN G R. Vision, touch and object manipulation in senegal parrots poicephalus senegalus [J]. Proc. Biol. Sci., 2011, 278(1725): 3687-3693.
10	HAGAN A A, HEATH J E. Regulation of heat loss in the duck by vasomotion in the bill [J]. J. Therm. Biol., 1980, 5(2): 95-101.
11	TATTERSALL G J, ANDRADE D V, ABE A S. Heat exchange from the toucan bill reveals a controllable vascular thermal radiator [J]. Science, 2009, 325(5939): 468-470.
12	GREENBERG R, CADENA V, DANNER R M, et al.. Heat loss may explain bill size differences between birds occupying different habitats [J/OL]. PLoS One, 2012, 7(7): e40933 [2021-11-07]. .
13	BURNESS G, HUARD J R, MALCOLM E, et al.. Post-hatch heat warms adult beaks: irreversible physiological plasticity in Japanese quail [J/OL]. P. Roy. Soc. B-biol. Sci., 2013, 280(1767):20131436 [2021-11-07]. .
14	TATTERSALL G J, ARNAOUT B, SYMONDS M R E. The evolution of the avian bill as a thermoregulatory organ [J]. Biol. Rev., 2017, 92(3): 1630-1656.
15	TATTERSALL G J, MILSOM W K. Transient peripheral warming accompanies the hypoxic metabolic response in the golden-mantled ground squirrel [J]. J. Exp. Biol., 2003, 206(1): 33-42.
16	SCOTT G R, VIVIANA C, TATTERSALL G J, et al.. Body temperature depression and peripheral heat loss accompany the metabolic and ventilatory responses to hypoxia in low and high altitude birds [J]. J. Exp. Biol., 2008, 211(8): 1326-1335.
17	SCOTT G R, HAWKES L A, FRAPPELL P B, et al.. How bar-headed geese fly over the Himalayas [J]. Physiology, 2015, 30(2): 107-115.
18	YAMAUCHI Y, YOSHIDA S, MATSUYAMA H, et al.. Morphologically abnormal beaks observed in chickens that were beak-trimmed at young ages [J]. J. Vet. Med. Sci., 2017, 79(9): 1466-1471.
19	LANDAUER W. Hereditary and induced cross-beak of fowl [J]. J. Exp. Zool., 1956, 132: 25-38.
20	LANDAUER W. Notes on cross-beak in fowl [J]. J. Genet., 1938, 37(1): 51-68.
21	BAI H, ZHU J, SUN Y Y, et al.. Identification of genes related to beak deformity of chickens using digital gene expression profiling [J/OL]. PLoS One, 2014, 9:e107050 [2021-11-07]. .
22	SHI L, LI Y L, BAI H. Phenotype characterization of crossed beaks in Beijing-You chickens based on morphological observation [J]. Poult. Sci., 2020, 99(11): 5197-5205.
23	朱静. 鸡喙组织致畸基因的筛选与验证[D].北京:中国农业科学院, 2012.
	ZHU J. Digital screening and identification of teratogenic genes underlying beak deformity in chickens [D]. Beijing: Chinese Academy of Agricultural Sciences, 2012.
24	白皓.鸡喙畸形性状全基因组关联分析及拷贝数变异研究[D]. 北京:中国农业科学院, 2017.
	BAI H. Genome-wide association studies and genome-wide detection of copy number variations for beak deformity in chickens [D]. Beijing: Chinese Academy of Agricultural Sciences, 2017.
25	LANGBERG B J, ARAI K, MINER R M. Transverse skeletal and dental asymmetry in adults with unilateral lingual posterior crossbite [J]. Am. J. Orthod. Dentofacial. Orthop., 2005, 127(1): 6-15.
26	YANG H J, HWANG S J. Change in condylar position in posterior bending osteotomy minimizing condylar torque in BSSRO for facial asymmetry [J]. J. Craniomaxillofac. Surg., 2014, 42(4): 325-332.
27	BELEZA-MEIRELES A, CLAYTON-SMITH J, SARAIVA J M, et al.. Oculo-auriculo-vertebral spectrum: a review of the literature and genetic update [J]. J. Genet., 2014, 51(10): 635-645.
28	BRANDSTETTER K A, PATEL K G. Craniofacial microsomia [J]. Facial. Plast. Surg. Clin. North. Am., 2016, 24(4): 495-515.
29	LI Q, ZHOU X, WANG Y, et al.. Facial paralysis in patients with hemifacial microsomia [J]. J. Craniofac. Surg., 2018, 29(6): 1633-1637.
30	HUTT F B. Eight new mutations in the domestic fowl [J]. Proc. Sixth. Int. Congr. Genet. Ithaca. N. Y., 1932, 2: 96.
31	SCHBAPEL J. KREUZSCHNABELBILDUNG [J]. Dtschtierarztl. Wschr., 1934, 42: 709-710.
32	SUN Y, LIU N, BAI H, et al.. Differential proteomic analysis to identify proteins associated with beak deformity in chickens [J]. Poult. Sci., 2019, 98(4): 1833-1841.
33	BAI H, SUN Y, LIU N, et al.. Single SNP- and pathway-based genome-wide association studies for beak deformity in chickens using high-density 600K SNP arrays [J/OL]. BMC Genom., 2018, 19(1): 501 [2021-11-07]. .
34	GUO D, HOLMLUND C, HENRIKSSON R, et al.. The LRIG gene family has three vertebrate paralogs widely expressed in human and mouse tissues and a homolog in Ascidiacea [J]. Genomics, 2004, 84(1): 157-165.
35	STUART H M, ROBERTS N A, BURGU B, et al.. LRIG2 mutations cause urofacial syndrome [J]. Am. J. Hum. Genet., 2013, 92(2): 259-264.
36	SCHNEIDER R A, HELMS J A. The cellular and molecular origins of beak morphology [J]. Science, 2003, 299(5606): 565-568.
37	ROBERTSON K, MASON I. Expression of ret in the chicken embryo suggests roles in regionalisation of the vagal neural tube and somites and in development of multiple neural crest and placodal lineages [J]. Mech. Dev., 1995, 53(3): 329-344.
38	GRIECO M, SANTORO M, BERLINGIERI M T, et al.. PTC is a novel rearranged form of the ret proto-oncogene and is frequently detected in vivo in human thyroid papillary carcinomas [J]. Cell, 1990, 60(4): 557-563.
39	PENNISI E. Developmental biology. Bonemaking protein shapes beaks of Darwin’s finches [J]. Science, 2004, 305(5689): 1383.
40	WU P, JIANG T, SUKSAWEANG S, et al. Molecular shaping of the beak [J]. Science, 2004, 305(5689): 1465-1466.
41	WU P, JIANG T, SHEN J, et al.. Morphoregulation of avian beaks: comparative mapping of growth zone activities and morphological evolution [J]. Dev. Dyn., 2006, 235(5): 1400-1412.
42	CHAI Y, JIANG X, ITO Y, et al.. Fate of the mammalian cranial neural crest during tooth and mandibular morphogenesis [J]. Development, 2000, 127(8): 1671-1679.
43	JIANG X, ISEKI S, MAXSON R E, et al.. Tissue origins and interactions in the mammalian skull vault [J]. Dev. Biol., 2002, 241(1): 106-116.
44	ERIN L E, ANDREW H J, JANE H, et al.. Neural crest-mediated bone resorption is a determinant of species-specific jaw length [J]. Dev. Biol., 2015, 408(1): 151-163.
45	ANDERSON R M, STOTTMANN R W, CHOI M, et al.. Endogenous bone morphogenetic protein antagonists regulate mammalian neural crest generation and survival [J]. Dev. Dyn., 2006, 235(9): 2507-2520.
46	MACKENZIE B A, WOLFF R, LOWE N, et al.. Twisted gastrulation limits apoptosis in the distal region of the mandibular arch in mice [J]. Dev. Biol., 2009, 328(1): 13-23.
47	STOTTMANN R W, ANDERSON R M, KLINGENSMITH J. The BMP antagonists chordin and noggin have essential but redundant roles in mouse mandibular outgrowth [J]. Dev. Biol., 2001, 240(2): 457-473.
48	BAI H, SUN Y, ZHU J, et al.. Study on LOC426217 as a candidate gene for beak deformity in chicken [J/OL]. BMC. Genet., 2016, 17(1): 44 [2021-11-07]..
49	白皓.北京油鸡喙畸形性状候选基因的转录水平研究及SNPs分析[D]. 扬州:扬州大学, 2013.
	BAI H. The mRNA expression and SNPs analysis of candidate genes associated with beak deformity trait in Beijing-You chickens [D]. Yangzhou: Yangzhou University, 2013.
50	SHI L, BAI H, LI Y, et al.. Analysis of DNA methylation profiles in mandibular condyle of chicks with crossed beaks using whole-genome bisulfite sequencing [J/OL]. Front. Genet., 2021, 12:680115 [2021-11-07]. .
51	SU J, SU J, RHEE Y, et al.. Fidgetin-like 1 gene inhibited by basic fibroblast growth factor regulates the proliferation and differentiation of osteoblasts [J]. J. Bone. Miner. Res., 2010, 22(6): 889-896.

品种 Strain	交叉喙发生率 Prevalence of crossed beaks/ %	参考文献 Reference
白来航鸡White Leghorn	0.20	［19］
Black Minorcas	1.60	［19］
Silver Spangled Hamburgh	2.50~3.30	［20］
洛岛红鸡Rhode Island Red	发生 Existence	［20］
Dark Cornish	发生 Existence	［20］
Appenzeller Barthuhn	7.40	［5］
Appenzeller Spitzhaubenhuhn	1.50	［5］
Schweizerhuhn	0.80	［5］
丝羽乌骨鸡 Silky chicken	1.00~3.00	［21］
惠阳胡须鸡 Huiyang Bearded chicken	1.00~3.00	［4］
北京油鸡 Beijing-You chicken	0.72~3.00	［22‑23］
象洞鸡 Xiangdong chicken	1.00~3.00	调查 Investigation
贵妃鸡 Houdan chicken	0.50	调查 Investigation
河田鸡 Hetian chicken	0.03~0.40	调查 Investigation
洪山鸡 Hongshan chicken	发生 Existence	调查 Investigation

品种 Strain	交叉喙发生率 Prevalence of crossed beaks/ %	参考文献 Reference
白来航鸡White Leghorn	0.20	［19］
Black Minorcas	1.60	［19］
Silver Spangled Hamburgh	2.50~3.30	［20］
洛岛红鸡Rhode Island Red	发生 Existence	［20］
Dark Cornish	发生 Existence	［20］
Appenzeller Barthuhn	7.40	［5］
Appenzeller Spitzhaubenhuhn	1.50	［5］
Schweizerhuhn	0.80	［5］
丝羽乌骨鸡 Silky chicken	1.00~3.00	［21］
惠阳胡须鸡 Huiyang Bearded chicken	1.00~3.00	［4］
北京油鸡 Beijing-You chicken	0.72~3.00	［22‑23］
象洞鸡 Xiangdong chicken	1.00~3.00	调查 Investigation
贵妃鸡 Houdan chicken	0.50	调查 Investigation
河田鸡 Hetian chicken	0.03~0.40	调查 Investigation
洪山鸡 Hongshan chicken	发生 Existence	调查 Investigation

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Research Progress on Crossed Beak in Chicken

鸡交叉喙研究进展

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