In order to understand the characteristics of potassium and chlorine contents in tobacco leaves, tobacco leaves of different varieties and soil samples were collected from 2013-2014 in Bozhou, Anhui Province, and the potassium and chlorine contents and soil physical and chemical characteristics were analyzed. The results showed that the potassium content of flue-cured tobacco leaves were 6.2~21.9 g/kg. The average potassium content of upper, middle and lower part tobacco leaves were 13.9 g/kg, 13.7 g/kg, and 11.7 g/kg, respectively. The leaf potassium content in over 70% samples were lower than 15 g/kg, while that of only 50% samples were higher than 10 g/kg. Just a few sampless potassium contents were higher than 20 g/kg. There was no significant difference of potassium content in the same position of leaves between difference areas in Bozhou. The potassium content in different varieties followed the order as Zhongyan 100 > Longjiang 911 > NC 89. Chlorine content of flue-cured tobacco leaves were 4.3~20.1 g/kg in Bozhou. The average chlorine content of upper, middle and lower tobacco leaves were 10.3 g/kg, 10.2 g/kg and 9.0 g/kg, respectively. The leaf chlorine contents in Lumiao and Shuanggou were lower than that in Zhangji. There was no significant difference of potassium content in the same position of leaves between varieties in Bozhou. Generally the potassium content in Bozhou tobacco leaves was low, their chlorine content was high, and potassium/chlorine was low. Therefore, how to increase the potassium content and reduce chlorine content was crucial for improving the quality of Bozhou tobacco leaves. In order to increase potassium content of tobacco leaf, we should improve fertilization way, such as applying root zone fertilization, and increasing irrigation during drought period. On the other hand, we should choose soil with low chlorine content as tobacco producing field, forbid to use chlorine fertilizer, and implement free flooding irrigation to reduce leaf chlorine content in Bozhou.